Triterpene saponins from the roots of Dipsacus asper and their protective effects against the A尾_25-35 induced cytotoxicity in PC12 cells

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• 作者：De Ji ; Yue Wu ; Bin Zhang ; Chun-Feng Zhang ; ^{zhangchunfeng67@163.com} ; Zhong-Lin Yang ; ^{yzl1950@tom.com}
• 关键词：Dipsacus asper ; Triterpene saponin ; Asperosaponin A&ndash ; C ; Amyloid 尾 ; Cytotoxic activity
• 刊名：Fitoterapia
• 出版年：2012
• 期刊代码：35_0367326x
• 类别：ch
• 出版时间：July, 2012
• 卷：83
• 期：5
• 页码：843-848
• 文件大小：357 K

摘要

Three new triterpene saponins, named asperosaponin A-C (1-3), together with seven known triterpene saponins (4-10) were isolated from the roots of Dipsacus asper. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1-3, 6-10 had significantly protective effects in PC12 cells against the A尾_25-35 induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823.