Designing and creating a modularized synthetic pathway in cyanobacterium Synechocystis enables production of acetone from carbon dioxide

详细信息	查看全文 | 推荐本文 |

• 作者：Jie Zhou ; Haifeng Zhang ; Yanping Zhang ; Yin Li ; ^yli@im.ac.cn ; Yanhe Ma
• 关键词：Ketones ; Acetone ; Biosynthesis ; CO2 ; Synechocystis sp. PCC 6803
• 刊名：Metabolic Engineering
• 出版年：2012
• 期刊代码：98_10967176
• 类别：ce
• 出版时间：July, 2012
• 卷：14
• 期：4
• 页码：394-400
• 文件大小：609 K

摘要

Ketones are a class of important organic compounds. As the simplest ketone, acetone is widely used as solvents or precursors for industrial chemicals. Presently, million tonnes of acetone is produced worldwide annually, from petrochemical processes. Here we report a biotechnological process that can produce acetone from CO₂, by designing and creating a modularized synthetic pathway in engineered cyanobacterium Synechocystis sp. PCC 6803. The engineered Synechocystis cells are able to produce acetone (36.0 mg l^鈭? culture medium) using CO₂ as the sole carbon source, thus opens the gateway for biosynthesis of ketones from CO₂.