Synthesis, characterization and antibacterial activity of new sulfonyl hydrazone derivatives and their nickel(II) complexes

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• 作者：Ü ; mmü ; han Ö ; zdemir Ö ; zmen ; Gü ; lç ; in Olgun
• 关键词：Aroylsulfonylhydrazone ; Ni(II) complexes ; Sulfonamide derivatives ; Antibacterial activity
• 刊名：Spectrochimica Acta Part A ; Molecular and Biomolecular Spectroscopy
• 出版年：2008
• 期刊代码：99_13861425
• 类别：ch
• 出版时间：August 2008
• 卷：70
• 期：3
• 页码：641-645
• 文件大小：291 K

摘要

Prophane sulfonic acid hydrazide (psh: CH₃CH₂CH₂SO₂NHNH₂) derivatives as salicylaldehydeprophanesulfonylhydrazone (salpsh), 5-methylsalicylaldehydeprophanesulfonylhydrazone (5-msalpsh), 2-hydroxyacetophenoneprophanesulfonylhydrazone (afpsh), 5-methyl-2-hydroxyacetophenoneprophanesulfonylhydrazone (5-mafpsh) and their Ni(II) complexes have been synthesized. The structure of these compounds has been investigated by using elemental analysis, FTIR, ¹H NMR, LC/MS, UV–vis spectrophotometric method, magnetic susceptibility and conductivity measurements. The complexes were found to have general compositions [NiL2]. Square-planer structures are proposed for the Ni(II) complexes on the basis of magnetic evidence, electronic spectra and TGA data. Bacterial activities of sulfonyl hydrazone compounds were studied against gram-positive bacteria: Staphylococcus aureus, Bacillus subtilis, Bacillus magaterium and gram-negative bacteria: Salmonella enteritidis, Escherichia coli by using minimum inhibitory concentrations (MICs) method.