Glucose sensitive poly (N-isopropylacrylamide) microgel based etalons
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- 作者：Courtney D. Sorrell (1)
Michael J. Serpe (1) michael.serpe@ualberta.ca - 关键词：Poly (N ; isopropylacrylamide) microgels – ; Color tunable materials – ; Fabry– ; P茅rot etalon – ; Stimuli responsive polymers – ; Metal– ; polymer hybrid structures – ; Glucose sensing
- 刊名：Analytical and Bioanalytical Chemistry
- 出版时间：March 2012
- 出版年：2012
- 期刊代码：8_1618-2642
- 类别：en
- 卷：402
- 期：7
- 页码：2385-2393
- 数据来源：sp
摘要
Thermoresponsive microgels have been shown to be an excellent platform for designing sensor materials. Recently, poly (N-isopropylacrylamide)-co-acrylic acid (pNIPAm-co-AAc) microgel based etalon materials have been described as direct sensing materials that can be designed to have a single, unique color. These color tunable materials show immense promise for sensing due to their spectral sensitivity and bright visual color. Here, we describe a proof-of-concept for etalon sensing of glucose. We found that aminophenylboronic acid (APBA)-functionalized pNIPAm-co-AAc microgels in an etalon respond to 3 mg/mL glucose concentrations by red shifting their reflectance peaks by 110 nm up to 150 nm. Additionally, APBA-functionalized pNIPAm-co-AAc microgels have a depressed volume phase transition temperature at 18–20 掳C, which shifts to 24–26 掳C after glucose binding. We also demonstrate that these materials show a marked visual color change, which is a first step towards developing direct read-out sensor devices.