Determination of molecular associations of some hydrophobic and hydrophilic bile acids by infrared and Raman spectroscopy
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- 作者：E. Lamcharfi ; C. Cohen-Solal ; M. Parquet ; C. Lutton ; J. Dupr茅 and C. Meyer
- 关键词：Key words Hydrophobic ; Hydrophilic bile acids
- 刊名：European Biophysics Journal
- 出版时间：March 1997
- 出版年：1997
- 期刊代码：32_0175-7571
- 类别：ph
- 卷：25
- 期：4
- 页码：285-291
- 数据来源：sp
摘要
The aim of this study was to analyse the Raman and infrared spectra of eight common mammalian bile acids in order to identify intermolecular interactions between hydroxyl and carbonyl groups. The results are considered in the light of the new hydrophilic/hydrophobic classification of bile acids. The alcohol OH group of the hydrophobic bile acids forms different intermolecular bonds. The most hydrophobic bile acid, lithocholic acid forms polymers, and this may explain its very low water solubility. The hydrophilic bile acids have some of their alcohol OH groups free of any intermolecular interaction. The strongly hydrophilic murideoxycholic acid also forms dimers, again consistent with a very low water solubility. The proposed structural arrangements are in agreement with published crystallographic studies.