Adsorption of proteins on a lipid bilayer
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- 作者：Vladimir P. Zhdanov and Bengt Kasemo
- 关键词：Proteins ; Lipids ; Adsorption energy ; Electrostatic interactions ; Poisson– ; Boltzmann equation
- 刊名：European Biophysics Journal
- 出版时间：October 2010
- 出版年：2010
- 期刊代码：32_0175-7571
- 类别：ph
- 卷：39
- 期：11
- 页码：1477-1482
- 数据来源：sp
摘要
In our analysis of protein adsorption on a lipid bilayer, the protein surface is considered to contain one or a few charged spots, and the bilayer contains a significant amount of lipids with oppositely charged head groups. After adsorption, a folded protein is assumed to change its shape slightly due to the electrostatic attraction, so that one of the spots forms a flat contact with the oppositely charged lipid heads of the lipid bilayer. With realistic parameters, this model predicts that the contribution of electrostatic interactions to the protein adsorption energy per charged amino acid–lipid pair is 16–25 kJ/mol. Thus, a few (four or five) pairs is sufficient for irreversible adsorption.