Poly(N-vinylpyrrolidone)-modified surfaces repel plasma protein adsorption

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• 作者：Xiao-li Liu (12)
  Zhao-qiang Wu (2) wzqwhu@suda.edu.cn
  Dan Li (12)
  Hong Chen (2)
• 关键词：Poly(N ; vinylpyrrolidone) &#8211 ; Surface modification &#8211 ; Protein adsorption &#8211 ; ATRP &#8211 ; Biocompatibility.
• 刊名：Chinese Journal of Polymer Science
• 出版时间：March 2012
• 出版年：2012
• 期刊代码：pc326_0256-7679
• 类别：ch
• 卷：30
• 期：2
• 页码：235-241
• 数据来源：sp

摘要

The present work aimed to study the interaction between plasma proteins and PVP-modified surfaces under more complex protein conditions. In the competitive adsorption of fibrinogen (Fg) and human serum albumin (HSA), the modified surfaces showed preferential adsorption of HSA. In 100%plasma, the amount of Fg adsorbed onto PVP-modified surfaces was as low as 10 ng/cm2, suggesting the excellent protein resistance properties of the modified surfaces. In addition, immunoblots of proteins eluted from the modified surfaces after plasma contact confirmed that PVP-modified surfaces can repel most plasma proteins, especially proteins that play important roles in the process of blood coagulation.