Determining important regulatory relations of amino acids from dynamic network analysis of plasma amino acids
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- 作者：Nahoko Shikata ; Yukihiro Maki ; Masahiko Nakatsui ; Masato Mori ; Yasushi Noguchi ; Shintaro Yoshida ; Michio Takahashi ; Nobuo Kondo and Masahiro Okamoto
- 关键词：Plasma amino acids ; Relation ; Regulation ; Network ; Amino acid deficiency ; Dynamic
- 刊名：Amino Acids
- 出版时间：January, 2010
- 出版年：2010
- 期刊代码：7_0939-4451
- 类别：bio
- 卷：38
- 期：1
- 页码：179-187
- 数据来源：sp
摘要
The changes in the concentrations of plasma amino acids do not always follow the flow-based metabolic pathway network. We have previously shown that there is a control-based network structure among plasma amino acids besides the metabolic pathway map. Based on this network structure, in this study, we performed dynamic analysis using time-course data of the plasma samples of rats fed single essential amino acid deficient diet. Using S-system model (conceptual mathematical model represented by power-law formalism), we inferred the dynamic network structure which reproduces the actual time-courses within the error allowance of 13.17%. By performing sensitivity analysis, three of the most dominant relations in this network were selected; the control paths from leucine to valine, from methionine to threonine, and from leucine to isoleucine. This result is in good agreement with the biological knowledge regarding branched-chain amino acids, and suggests the biological importance of the effect from methionine to threonine.