Alterations in D-amino acid levels in the brains of mice and rats after the administration of D-amino acids
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- 作者：A. Morikawa ; K. Hamase ; T. Inoue ; R. Konno and K. Zaitsu
- 关键词：Keywords ; D ; Amino acid – ; Brain distribution – ; D ; Amino ; acid oxidase – ; HPLC
- 刊名：Amino Acids
- 出版时间：January, 2007
- 出版年：2007
- 期刊代码：7_0939-4451
- 类别：bio
- 卷：32
- 期：1
- 页码：13-20
- 数据来源：sp
摘要
To mutant ddY/DAO− mice lacking D-amino-acid oxidase activity and normal ddY/DAO+ mice, five D-amino acids (D-Asp, D-Ser, D-Ala, D-Leu and D-Pro) were orally administered for two weeks, and the D-amino acid levels were examined in seven brain regions. The levels of D-Asp markedly increased in the pituitary and pineal glands in both strains. In the ddY/DAO+ mice, the levels of the other D-amino acids did not significantly change in most of the brain regions. While in the ddY/DAO− mice the levels of D-Ser significantly increased in most of the brain regions except for the cerebrum and hippocampus. The levels of D-Ala and D-Leu increased in all regions but the levels of D-Pro did not significantly change. The same five D-amino acids were intravenously injected into Wistar rats and the D-amino acid levels in their brains were examined for 60 min after the administration. The levels of D-Asp markedly increased in the pineal gland 3 min after the administration, while the levels of D-Ser, D-Ala, and D-Pro increased both in the pineal and pituitary glands, the levels of D-Leu increased in all brain regions. These results are useful for the elucidation of the origins and regulation of D-amino acids in the mammalian body.