Enantiopure 尾³-amino acids-2,2-d₂ via homologation of proteinogenic 伪-amino acids

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• 作者：R. Caputo and L. Longobardo
• 关键词：Keywords ; β ; 3 ; amino acids – ; α ; amino acid homologation – ; C ; 2 ; dideuterated amino acids – ; 2 ; aminoalcohols ; d2 – ; 2 ; aminoiodides ; d2 – ; β ; 3 ; amino nitriles ; d2
• 刊名：Amino Acids
• 出版时间：April, 2007
• 出版年：2007
• 期刊代码：7_0939-4451
• 类别：bio
• 卷：32
• 期：3
• 页码：401-404
• 数据来源：sp

摘要

A procedure for the synthesis of enantiopure β3-amino acids from proteinogenic α-amino acids, developed by our group a few years ago, has been modified to enable the production of C-2 fully deuterated, C-protected β3-amino acids and, even more important, the synthesis of valuable deuterium labelled N(Boc)-protected chiral synthons, such as 2-aminoalcohols, 2-aminoiodides, and β3-amino nitriles.