New approaches to the endocrine prevention and treatment of breast cancer
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- 作者：Anthony Howell ; Sacha J. Howell and D. Gareth Evans
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版时间：June 2003
- 出版年：2003
- 期刊代码：24_0344-5704
- 类别：med
- 卷：52
- 期：0
- 页码：39-44
- 数据来源：sp
摘要
All major endocrine prevention approaches act via the estrogen receptor (ER). A simple hypothesis concerning ER expression and breast cancer risk is outlined. We review breast cancer prevention trials with tamoxifen, raloxifene, aromatase inhibitors, and ovarian suppression. Current and planned endocrine prevention trials in populations of pre- and postmenopausal women at risk of breast cancer are summarized and endocrine therapy after primary surgery and for advanced disease discussed.