Polymerized mixed aggregates containing gadolinium complex and CCK8 peptide
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- 作者：Mauro Vaccaro ; Gaetano Mangiapia ; Antonella Accardo ; Diego Tesauro ; Eliana Gianolio ; Henrich Frielinghaus ; Giancarlo Morelli and Luigi Paduano
- 关键词：Polymerizable ; Surfactants ; MRI ; Peptides ; SANS ; Micelles
- 刊名：Colloid & Polymer Science
- 出版时间：December, 2008
- 出版年：2008
- 期刊代码：60_0303-402X
- 类别：bio
- 卷：286
- 期：14-15
- 页码：1643-1652
- 数据来源：sp
摘要
Two novel amphiphilic unimers containing an aliphatic hydrophobic chain (PDA) with two C≡C triple bonds and hydrophilic heads presenting the chelating agent DTPAGlu and the CCK8 bioactive peptide, respectively, have been prepared by solid phase synthesis. Aggregates obtained by mixing together PDA-DTPAGlu, or its Gd(III) complex, and PDA-L2-CCK8 in 70/30 molar ratio before and after a polymerization process carried out by UV irradiation have been structurally characterized by means of small angle neutron scattering. The relaxivity properties of aggregates containing Gadolinium complexes have also been investigated. Elongated mixed micelles have been observed, in which the relaxivity value r 1p for each Gadolinium complex, measured at 20 MHz and 298 K, is around 12 mM–1 s–1.