The V-ATPase inhibitors concanamycin A and bafilomycin A lead to Golgi swelling in tobacco BY-2 cells
| 详细信息 | 推荐本文 | |
- 作者：D. G. Robinson ; S. Albrecht and Y. Moriysu
- 关键词：Key words ; Bafilomycin A ; Concanamycin A ; Tobacco BY ; 2 cells ; Golgi apparatus ; Vacuolation.
- 刊名：Protoplasma
- 出版时间：December 2004
- 出版年：2004
- 期刊代码：223_0033-183X
- 类别：bio
- 卷：224
- 期：3-4
- 页码：255-260
- 数据来源：sp
摘要
Concanamycin A and bafilomycin A are well-known inhibitors of V-ATPase activity. It is known that they interfere with intracellular protein trafficking in both animal and plant cells, but a cellular target for their action in plant cells has not been defined. Here we show that treatment with these inhibitors leads to a massive vacuolation of the Golgi apparatus. The effect is similar, but not identical, to that previously described for the Na+/K+ ionophores and is reversible after washing.