Evaluation of urinary biomarkers of exposure to benzene: correlation with blood benzene and influence of confounding factors
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- 作者：Perrine Hoet ; Erika De Smedt ; Massimo Ferrari ; Marcello Imbriani ; Luciano Maestri ; Sara Negri ; Peter De Wilde ; Dominique Lison and Vincent Haufroid
- 关键词：Benzene ; S ; Phenylmercapturic acid ; Sorbic acid ; t ; t ; Muconic acid ; Biological monitoring
- 刊名：International Archives of Occupational and Environmental Health
- 出版时间：August, 2009
- 出版年：2009
- 期刊代码：82_0340-0131
- 类别：soc
- 卷：82
- 期：8
- 页码：985-995
- 数据来源：sp
摘要
Purpose trans,trans-Muconic acid (t,t-MA) is generally considered as a useful biomarker of exposure to benzene. However, because of its lack of specificity, concerns about its value at low level of exposure have recently been raised. The aim of this study was (a) to compare t,t-MA, S-phenylmercapturic acid (SPMA) and benzene (B-U) as urinary biomarkers of exposure to low levels of benzene in petrochemical workers and, (b) to evaluate the influence of sorbic acid (SA) and genetic polymorphisms of biotransformation enzymes on the excretion of these biomarkers.