Lipase-catalyzed synthesis of capsaicin analogs by transacylation of capsaicin with natural oils or fatty acid derivatives in n-hexane
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- 作者：Kobata ; Kenji ; Kobayashi ; Mamiko ; Tamura ; Yukiyoshi ; Miyoshi ; Shozo ; Ogawa ; Susumu ; Watanabe ; Tatsuo
- 关键词：capsaicin analog ; lipase ; natural oil ; transacylation ; triacylglyceride
- 刊名：Biotechnology Letters
- 出版时间：1999
- 出版年：1999
- 期刊代码：6_01415492
- 类别：en
- 卷：21
- 期：6
- 页码：547-550
- 数据来源：sp
摘要
Transacylation of capsaicin with triolein using a commercial lipase gave olvanil in an 85% yield at 70 °C for 144 h. When olive oil was employed, the major product was olvanil (62%). Safflower oil gave a mixture of olvanil (39%) and linoleoyl vanillylamide (32%). Perilla oil gave linolenoyl vanillylamide (13%). Myristic acid and its methyl ester could be used as an acyl donor, and myristoyl vanillylamide was obtained in 20–78% using several lipases.