Study on the Sternberg Paradigm in Cirrhotic Patients Without Overt Hepatic Encephalopathy

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• 作者：Piero Amodio ; Piergiorgio Marchetti ; Franco Del Piccolo ; Cristiano Rizzo ; Rosa Maria Iemmolo ; Lorenza Caregaro ; Giorgio Gerunda and Angelo Gatta
• 关键词：Sternberg paradigm ; Number Connection Test ; subclinical hepatic encephalopathy ; electroencephalography ; spectral analysis
• 刊名：Metabolic Brain Disease
• 出版时间：1998
• 出版年：1998
• 期刊代码：24_08857490
• 类别：edu
• 卷：13
• 期：2
• 页码：159-172
• 数据来源：sp

摘要

Memory dysfunction is reported in cirrhotics. The aim of this paper was to increase insight into memory function of cirrhotic patients without overt hepatic encephalopathy. Eighty-six consecutive cirrhotics without overt hepatic encephalopathy (aged 54±10 yr., mean±s.d.) and 28 controls (52±10 yr.) with comparable education level were enrolled. Seventeen patients were class A, 55 class B, 14 class C according to Child-Pugh classification; 29 had alcoholic cirrhosis. The presence of subclinical signs of central nervous system dysfunction were assessed by Number Connection Test (NCT) and quantified EEG analysis. Memory scanning was evaluated by reaction times (RTs) in the Sternberg paradigm. MANOVA analysis showed that RTs were higher (F_1,99=11, p_1,110=10, p_1,110=2, p=n.s.). In cirrhotics, an interaction Child-Pugh class x memory set size was found (F_2,146=4, p_1,71=4, p_1,82=11, p_2,70=6, p