Implementation of a Computational Model of the Innate Immune System
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- 作者：Alexandre Bittencourt Pigozzo (1) alexbprr@gmail.com
Gilson Costa Macedo (1) gilson.macedo@ufjf.edu.br
Rodrigo Weber dos Santos (1) rwdsantos@yahoo.com
Marcelo Lobosco (1) marcelo.lobosco@ufjf.edu.br - 关键词：Immune Modelling – ; Innate Immune System – ; Acute Inflammation – ; Partial Differential Equations – ; Finite Difference Method
- 刊名：Lecture Notes in Computer Science
- 出版时间：2011
- 出版年：2011
- 期刊代码：99_0302-9743
- 类别：cp
- 卷：6825
- 期：1
- 页码：95-107
- 数据来源：sp
摘要
In the last few years there has been an increasing interest in mathematical and computational modelling of the human immune system (HIS). Computational models of the HIS dynamics may contribute to a better understanding of the complex phenomena associate to the immune system, and support the development of new drugs and therapies for different diseases. However, the modelling of the HIS is an extremely hard task that demands huge amount of work to be performed by multidisciplinary teams. In this scenario, the objective of this work is to model the dynamics of some cells and molecules of the HIS during an immune response to lipopolysaccharide (LPS) in a section of the tissue. The LPS constitutes the cellular wall of Gram-negative bacteria, and it is a highly immunogenic molecule, which means that it has a remarkable capacity to elicit strong immune responses.