Detection of tumour hypoxia: comparison between EF5 adducts and [¹⁸F]EF3 uptake on an individual mouse tumour basis

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• 作者：P. Mahy ; M. De Bast ; J. Gillart ; D. Labar and V. Gr茅goire
• 关键词：Tumour hypoxia ; EF5 ; [18F]EF3 ; Immunofluorescence ; PET scan
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版时间：May 2006
• 出版年：2006
• 期刊代码：62_1619-7070
• 类别：med
• 卷：33
• 期：5
• 页码：553-556
• 数据来源：sp

摘要

In the framework of the preclinical validation of the hypoxic tracer [18F]EF3, a comparison was performed between uptake of [18F]EF3 and EF5 adducts detected by immunofluorescence in MCa-4, FSA, FSAII, Sa-NH and NFSA tumour-bearing mice. Mice were allowed to breath carbogen (5%CO₂, 95%O₂), 21%oxygen or 10%oxygen. A significant correlation (r 2=0.57; p<0.01) was found between the [18F]EF3 tumour-to-muscle ratio and the fluorescence intensity of EF5.