Synthesis of Cyclohexane Containing 5'-O-Glycine Derivatives of Uridine as Potential Inhibitors of UDP-glucuronosyltransferase
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- 作者：Dimitar K. Alargov A1 ; Roumyana G. Gugova A1 ; Pavleta S. Denkova A2 ; Gunther M眉ller A3 ; Evgeny V. Golovinsky A1
- 关键词：Uridine ; 5鈥?O-Amino acid derivatives ; Cyclohexanecarboxylic acid ; Cyclohexylpropionic acid ; UDP -Glucuronosyltransferase.
- 刊名：Monatshefte für Chemie / Chemical Monthly
- 出版时间：July 1999
- 出版年：1999
- 期刊代码：99_0026-9247
- 类别：ch
- 卷：130
- 期：7
- 页码：937-943
- 数据来源：sp
摘要
Summary. In order to design potential inhibitors of UDP-glucuronosyltransferase, two different pathways for the synthesis of cyclohexane containing 5'-O-glycine derivatives of uridine were developed, one starting with the cyclohexyl moiety, and a second one beginning with the uridine moiety. Thus, 5'-O-(cyclohexylcarboxyl-glycyl)-2',3'-O-isopropylideneuridine and 5'-O-(cyclohexylpropionyl-glycyl)-2',3'-O-isopropylideneuridine were obtained. According to the results, the second approach is more convenient.