The association of skin diseases with human herpesvirus 8 infection in HIV carriers
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- 作者：P. I. Na Ayuthaya ; R. Inagi ; W. Auwanit ; P. Warachit ; P. Kullavanijaya ; V. Wessagowit ; R. Ungpakorn ; N. Loaphoomphan ; P. Piradhammanon and K. Yamanishi
- 刊名：Archives of Virology
- 出版时间：October 1998
- 出版年：1998
- 期刊代码：17_0304-8608
- 类别：med
- 卷：143
- 期：10
- 页码：1881-1892
- 数据来源：sp
摘要
The seroprevalence to Kaposi’s sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 (HHV-8) was surveyed in human immunodeficiency virus type 1 (HIV-1) carriers with or without skin diseases, and also in HIV-1 negative individuals in Thailand. Using an immunofluorescence assay, the seropositive rates to lytic antigens of HHV-8 in HIV-1 carriers with or without skin diseases were 25%and 7.4%, respectively, but none of HIV-1 negative individuals had antibody. The seroprevalence to HHV-8 antigens was high in HIV positive individuals with low CD4/CD8 ratio, suggesting that HHV-8 is reactivated during the immunosuppressive state. Several polypeptides with apparent molecular weights of 34–38,000 and 40,000, which were specific to HHV-8, were identified by the immunoprecipitation test using the seropositive sera. Our results suggested that HHV-8 co-existed with HIV in HIV-1 carriers and the existence of HHV-8 may be associated with clinical features in the skin.