Age-related Changes in the Insulin Receptor 尾 in the Gerbil Hippocampus
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- 作者：Chan Woo Park ; Ki-Yeon Yoo ; In Koo Hwang ; Jung Hoon Choi ; Choong Hyun Lee ; Ok Kyu Park ; Jun Hwi Cho ; Yun Lyul Lee ; Hyung-Cheul Shin and Moo-Ho Won
- 关键词：Insulin receptor β ; ; Aging ; Gerbil ; Hippocampus
- 刊名：Neurochemical Research
- 出版时间：December, 2009
- 出版年：2009
- 期刊代码：43_03643190
- 类别：cp
- 卷：34
- 期：12
- 页码：2154-2162
- 数据来源：sp
摘要
The insulin receptor has been reported to be associated with memory formation via the hippocampus. In this study, we observed age-related changes in the insulin receptor β immunoreactivity and its protein levels in the hippocampus of gerbils of various ages in order to identify the correlation between the insulin receptor β and aging processes in the hippocampus. Insulin receptor β immunoreactivity was mainly detected in the molecular and polymorphic layers of the dentate gyrus, and in mossy fibers, Schaffer collaterals, alveus and stratum lacunosum-moleculare of the hippocampus proper (CA1-3) of gerbils at postnatal month 1 (PM 1). Insulin receptor β immunoreactivity decreased with age in all of these structures, except for the alveus. Reduction of the insulin receptor β immunoreactivity was prominent in the molecular layer of the dentate gyrus at PM 6 and in the stratum lacunosum-moleculare of the CA1 region at PM 12, while insulin receptor β immunoreactivity was decreased in other regions in the PM 18 groups. In addition, insulin receptor β protein level in the whole hippocampus was slightly increased at PM 3, and it decreased in an age-dependent manner from PM 6 to PM 24. These reductions of the insulin receptor β in the hippocampus may be associated with age-related memory deficits in gerbils.