Neutrophil-Derived Hydroxyl Radicals Mediate Interleukin-8-Induced Increases in Tetragastrin-Stimulated Acid Secretion in Rats
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- 作者：Koji Yakabi ; Harumi Mimura ; Hitoshi Iwabuchi ; Shoki Ro ; Hideo Kamiichi ; Seiichi Miura and Takashi Nakamura
- 关键词：interleukin ; 8 ; neutrophil ; hydroxyl radicals ; acid secretion ; gastric lumen perfused rats
- 刊名：Digestive Diseases and Sciences
- 出版时间：2003
- 出版年：2003
- 期刊代码：5_01632116
- 类别：bus
- 卷：48
- 期：6
- 页码：1081-1087
- 数据来源：sp
摘要
Until recently, the secretion of gastric acid, which plays an important role in the pathogenesis of peptic ulcer, was thought to be controlled by diet, the autonomic nerves and gut hormones. However, peptic ulcer is now known to be caused by the infection with Helicobacter pylori (H. pylori), so it is possible that inflammation modifies the secretion of gastric acid. We used gastric-lumen-perfused rats to first examine the effect of interleukin-8 (IL-8) on acid secretion and then the involvement of free radicals and neutrophils in the action of IL-8. IL-8 enhanced tetragastrin-stimulated acid secretion and free radical scavengers or inhibitors and the pretreatment with anti-rat neutrophil serum inhibited this effect, which indicates that IL-8 enhances gastrin-stimulated acid secretion and that neutrophil-derived hydroxyl radicals mediate the IL-8-induced increase in acid secretion.