Vitamin D status is associated with disease-free survival and overall survival time in patients with squamous cell carcinoma of the upper aerodigestive tract
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- 作者：Markus Gugatschka (1) markus.gugatschka@klinikum-graz.at
Karl Kiesler (1)
Barbara Obermayer-Pietsch (2)
Andrea Groselj-Strele (3)
Antonia Griesbacher (3)
Gerhard Friedrich (1) - 关键词：Vitamin D status – ; 25 ; Hydroxyvitamin D (25(OH)D) – ; Head and neck squamous cell carcinoma (HNSCC)
- 刊名：European Archives of Oto-Rhino-Laryngology
- 出版时间：August 2011
- 出版年：2011
- 期刊代码：53_0937-4477
- 类别：med
- 卷：268
- 期：8
- 页码：1201-1204
- 数据来源：sp
摘要
Considerable clinical and experimental data suggest that vitamin D plays a role in pathogenesis and progression of cancer; nevertheless clinical data for head and neck squamous cell carcinoma (HNSCC) are not available. The aim of our study was to associate tumor and clinical characteristics with status of vitamin D [25-hydroxyvitamin D (25(OH)D)]. 88 patients with newly diagnosed squamous cell carcinoma of the head and neck were included in the study. A blood draw was taken at the time of diagnosis. The observation period lasted from 2006 until 2010. Results: When compared to a cohort from an epidemiological study, serum levels of 25(OH)D were significantly reduced in patients with HNSCC. We furthermore found disease-free survival, as well as overall survival times to be significantly associated with 25(OH)D levels. In conclusion, results from our study suggest an influence of vitamin D status on cancer incidence, as well as on mortality of HNSCC.