The role of brain infarcts and hippocampal atrophy in subcortical ischaemic vascular dementia
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- 作者：G. Gainotti ; A. Acciarri ; A. Bizzarro ; C. Marra ; C. Masullo ; S. Misciagna ; T. Tartaglione ; A. Valenza and C. Colosimo
- 关键词：Key words Multi– ; infarct dementia ; Alzheimers disease ; Brain infarcts ; Hippocampal atrophy
- 刊名：Neurological Sciences
- 出版时间：October 2004
- 出版年：2004
- 期刊代码：164_1590-1874
- 类别：med
- 卷：25
- 期：4
- 页码：192-197
- 数据来源：sp
摘要
We investigated if, in patients with vascularlesions, the variable that best discriminated demented fromnon–demented patients was the severity of the vascularpathology or the degree of hippocampal atrophy. A total of39 patients multiple subcortical infarcts, who could be consideredas possible vascular dementia with small vesselpathology, with underwent a neuropsychological study andbrain magnetic resonance imaging (MRI) DSM IV criteriasupported by neuropsychological data were used to distinguishdemented from non–demented patients. The MRI studytook into account the degree of hippocampal atrophy (hippocampalheight and interuncal distance) and the severity ofvascular pathology (number of brain infarcts). The distributionof lesions and a factor analysis showed that hippocampalatrophy is a better predictor of dementia than the numberof brain infarcts. Multiple subcortical infarcts alone are probablynot able to cause clinical dementia but the presence ofvascular lesions increases the expression of concomitantAlzheimers disease.