Vincristine treatment of nephrotic syndrome complicated by Kimura disease
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- 作者：Annette Connelly ; Harley R. Powell ; Yuen F. Chan ; David Fuller and Russell G. Taylor
- 关键词：Nephrotic syndrome ; Eosinophilia ; Kimura disease ; Vincristine
- 刊名：Pediatric Nephrology
- 出版时间：April 2005
- 出版年：2005
- 期刊代码：180_0931-041X
- 类别：med
- 卷：20
- 期：4
- 页码：516-518
- 数据来源：sp
摘要
Kimura disease is a rare inflammatory condition of unknown aetiology. It typically presents in young Asian males with the triad of non-tender subcutaneous swellings in the head and neck region, peripheral eosinophilia and raised serum IgE. About 16%of cases have associated renal disease. We present the case of a 10-year-old boy with a past history of steroid responsive, frequently relapsing nephrotic syndrome who developed a right submandibular swelling and eosinophilia. Kimura disease was diagnosed on the basis of clinical and histological findings. The condition recurred during relapses of nephrotic syndrome. Because of poor adherence with oral medication, our patient was treated with intravenous vincristine with synchronous remissions of his nephrotic syndrome and Kimura swellings on each occasion.