Dietary α-Linolenic Acid Increases the Biosynthesis of the Choline Glycerophospholipids from [14C]CDPcholine in Rat Liver and Kidney But Not in Brain
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- 作者：Kim ; Kye S. ; Park ; Eek J. ; Lee ; Chul W. ; Joo ; Han T. ; Yeo ; Young K.
- 关键词：Linoleic acid ; ; linolenic acid ; arachidonate ; eicosapentaenoate ; docosapentaenoate ; docosahexaenoate ; CDPcholine ; CDPethanolamine ; liver ; kidney ; brain
- 刊名：Neurochemical Research
- 出版时间：1997
- 出版年：1997
- 期刊代码：43_03643190
- 类别：cp
- 卷：22
- 期：10
- 页码：1291-1297
- 数据来源：sp
摘要
The effect of feeding rats for 30 days with diets containing high levels of linoleic acid (sunflower oil, SO) or α-linolenic acid (perilla oil, PO) was studied in the liver, kidney and brain. The PO group showed a higher labeling of choline glycerophospholipids (CGP) in liver and kidney but no difference with the SO group in ethanolamine glycerophospholipids (EGP) labeling. The brain displayed the lowest incorporation of both precursors and no difference between the two diets. Analyses of brain CGP and EGP fatty acid compositions showed that in the PO group the ratio n-6/n-3 was lower than in the SO group, mainly as a consequence of lower levels of n-6 fatty acids. The mole % of docosahexaenoate (DHA) in these lipids was the same for both groups and only triacylglycerols (TAG) displayed a higher DHA. Therefore, at least in the brain, the magnitude of fatty acid changes observed in CGP and EGP for the PO group does not affect the uptake/incorporation of the precursors into phospholipids.