Antigenic Differences between apo-B in Native and Circulating Modified Low-Density Lipoproteins
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- 作者：I. V. Suprun ; A. A. Melnichenko ; E. V. Yanushevskaya ; T. N. Vlasik ; I. A. Sobenin ; O. M. Panasenko and A. N. Orekhov
- 关键词：low ; density lipoproteins ; modified low ; density lipoproteins ; apo ; B ; atherosclerosis
- 刊名：Bulletin of Experimental Biology and Medicine
- 出版时间：2004
- 出版年：2004
- 期刊代码：16_00074888
- 类别：mat
- 卷：138
- 期：1
- 页码：42-44
- 数据来源：sp
摘要
The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions.