Partial volume effect-corrected FDG PET and grey matter volume loss in patients with mild Alzheimer鈥檚 disease
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- 作者：Miharu Samuraki ; Ichiro Matsunari ; Wei-Ping Chen ; Kazuyoshi Yajima ; Daisuke Yanase ; Akihiko Fujikawa ; Nozomi Takeda ; Shintaro Nishimura ; Hiroshi Matsuda and Masahito Yamada
- 关键词：Alzheimer’ ; s disease ; FDG ; PVE ; Cortical atrophy ; Hippocampus
- 刊名：European Journal of Nuclear Medicine and Molecular Imaging
- 出版时间：October, 2007
- 出版年：2007
- 期刊代码：62_1619-7070
- 类别：med
- 卷：34
- 期：10
- 页码：1658-1669
- 数据来源：sp
摘要
Purpose Although 18F-fluorodeoxyglucose (FDG) PET is an established imaging technique to assess brain glucose utilisation, accurate measurement of tracer concentration is confounded by the presence of partial volume effect (PVE) due to the limited spatial resolution of PET, which is particularly true in atrophic brains such as those encountered in patients with Alzheimer’s disease (AD). Our aim was to investigate the effects of PVE correction on FDG PET in conjunction with voxel-based morphometry (VBM) in patients with mild AD.