Biopotentials of secondary metabolites isolated from marine sponges
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- 作者：Joseph Selvin and A.P. Lipton
- 关键词：sponge ; secondary ; metabolites ; Dendrilla nigra ; Axinella donnani ; Clathria gorgonoides ; antibacterial ; brineshrimp ; cytotoxicity ; larvicidal ; antifouling ; ichthyotoxic
- 刊名：Hydrobiologia
- 出版时间：February, 2004
- 出版年：2004
- 期刊代码：17_09218971
- 类别：soc
- 卷：513
- 期：1-3
- 页码：231-238
- 数据来源：sp
摘要
The secondary metabolites of three sponges collected as bycatch in the fishing nets were explored for biological potencies. The sponge Dendrilla nigraexhibited wider biological activity. It showed potent activity in antibacterial, brineshrimp cytotoxicity, larvicidal, antifouling and ichthyotoxic assays. One of the well-studied cytotoxic sponge Axinella donnaniwas least active in brineshrimp cytotoxicity assay. The secondary metabolites of Clathria gorgonoideswere highly cytotoxic albeit it showed least activity in other bioassays. Based on the present findings, it could be inferred that the bioassay-guided fractionation and purification of D. nigramay come up with potent bioactive drugs.