A population-based LD map of the human chromosome 6p
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- 作者：Hong Xiang Yu ; Jer-Ming Chia ; Guillaume Bourque ; Marie Vivien Wong ; Soh Ha Chan and Ee Chee Ren
- 关键词：Major histocompatibility complex (MHC) ; Linkage disequilibrium ; Chromosome 6p ; Human genome ; Single nucleotide polymorphisms (SNPs)
- 刊名：Immunogenetics
- 出版时间：September 2005
- 出版年：2005
- 期刊代码：108_0093-7711
- 类别：bio
- 卷：57
- 期：8
- 页码：559-565
- 数据来源：sp
摘要
The recent publication of the complete sequence of human chromosome 6 provides a platform from which to investigate genomic sequence variation. We report here a detailed linkage disequilibrium (LD) pattern map across the entire human chromosome 6p by using a set of 1152 single nucleotide polymorphisms (SNPs) in a population of 198 Singaporean Chinese, with 326 SNPs focused in the major histocompatibility complex (MHC) region. Our analysis shows some unexpectedly high segments of strong LD in a 10-Mb region that includes the extremely polymorphic and gene-rich MHC loci and many non-MHC genes. These include the telomeric peri-MHC region that harbors olfactory receptors, histones and zinc finger clusters, and the centromeric peri-MHC region that contains several unknown open reading frames. The data also help refine a human–mouse synteny break in the region between 28.6 and 29.4 Mb. The population-based LD map presented here will provide an essential resource for understanding the genomic sequence variation of chromosome 6p and LD mapping of disease genes of complex genetic traits.