Macrolide-resistant Mycoplasma pneumoniae: characteristics of isolates and clinical aspects of community-acquired pneumonia
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- 作者：Miyuki Morozumi ; Takashi Takahashi and Kimiko Ubukata
- 关键词：Mycoplasma pneumoniae ; Macrolide resistance ; Mechanisms of antimicrobial resistance ; Community ; acquired pneumonia ; Clinical features ; Real ; time PCR
- 刊名：Journal of Infection and Chemotherapy
- 出版时间：April, 2010
- 出版年：2010
- 期刊代码：126_1341-321X
- 类别：med
- 卷：16
- 期：2
- 页码：78-86
- 数据来源：sp
摘要
Mycoplasma pneumoniae is one of the main pathogens causing community-acquired respiratory tract infections in children and adults. Macrolide (ML) antibiotics are recognized generally as first-choice agents for M. pneumoniae infections, and these antibiotics were thought to have excellent effectiveness against M. pneumoniae for many years. In 2000, however, M. pneumoniae showing resistance to macrolides was isolated from clinical samples obtained from Japanese pediatric patients with community-acquired pneumonia (CAP). Since then, prevalence of ML-resistant M. pneumoniae isolates in pediatric patients has increased rapidly. In 2007, ML-resistant M. pneumoniae isolates were obtained from Japanese adults with CAP; numbers of such isolates also have gradually increased in Japan. Recently, similar antimicrobial resistance in M. pneumoniae has begun to emerge worldwide. In this review, we focus on changes of ML-resistant M. pneumoniae from year to year and consider resistance mechanisms as well as clinical features of patients with resistant M. pneumoniae infection.