Transcription factors NFAT2 and Egr1 cooperatively regulate the maturation of T-lymphoma in vitro
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- 作者：E. K. Koltsova ; D. L. Wiest and T. P. Vavilova
- 关键词：β ; selection ; Egr ; NFAT ; pre ; TCR ; T ; lymphocytes
- 刊名：Biochemistry (Moscow)
- 出版时间：September, 2007
- 出版年：2007
- 期刊代码：12_00062979
- 类别：mat
- 卷：72
- 期：9
- 页码：954-961
- 数据来源：sp
摘要
We have demonstrated that transcription factors Egrl and NFAT2 cooperate in regulation of the early stages of T-lymphocyte development, whereas the related factors Egr2 and Egr3 do not cooperate with NFAT2. Egrl and NFAT2 are shown to cooperatively control gene expression of the regulatory factor Id3 and recombinase Rag2, whose functions are critical for T-lymphocyte differentiation. Thus, the concerted action of the transcription factors Egrl and NFAT2 can play a crucial role in regulation of the T cell differentiation in vitro due to the cooperative regulation of Id3 and Rag2 gene expression.