Fetal environment, epigenetics, and pediatric renal disease

详细信息

下载全文

推荐本文 |

• 作者：Robert Woroniecki (1)
  Anil Bhanudas Gaikwad (2)
  Katalin Susztak (23) Katalin.susztak@einstein.yu.edu
• 关键词：Epigenetics &#8211 ; Intrauterine environment &#8211 ; Histone modification &#8211 ; DNA methylation
• 刊名：Pediatric Nephrology
• 出版时间：May 2011
• 出版年：2011
• 期刊代码：180_0931-041X
• 类别：med
• 卷：26
• 期：5
• 页码：705-711
• 数据来源：sp

摘要

The notion that some adult diseases may have their origins in utero has recently captured scientists’ attention. Some of these effects persist across generations and may involve epigenetic mechanisms. Epigenetic modifications, DNA methylation together with covalent modifications of histones, alter chromatin density and accessibility of DNA to cellular machinery, modulating the transcriptional potential of the underlying DNA sequence. Here, we will discuss the different epigenetic modifications and their potential role in and contribution to renal disease development.