Reversed-Phase Liquid Chromatographic Separation, on Cellulose Chiral Stationary Phases, of the Stereoisomers of Methoxytetra-hydronaphthalene Derivatives, New Agonist and Antagonist Ligands for Melat

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• 作者：E. Lipka ; C. Descamps ; C. Vaccher and J. P. Bonte
• 关键词：Column liquid chromatography ; Chiral stationary phases ; Enantiomer separation ; Melatoninergic derivatives
• 刊名：Chromatographia
• 出版时间：February 2005
• 出版年：2005
• 期刊代码：19_0009-5893
• 类别：ph
• 卷：61
• 期：3-4
• 页码：143-149
• 数据来源：sp

摘要

A stereoselective high-performance liquid chromatographic method has been established for chiral separation of melatoninergic derivatives with one or two chiral centers, new agonist and antagonist ligands for melatonin receptors. Reversed-phase separations were performed on cellulose-based chiral stationary phases—tris-3,5-dimethylphenylcarbamate (Chiralcel OD-RH) or tris-methylbenzoate (Chiralcel OJ-R). Water–modifier (methanol or acetonitrile) mixtures in different proportions were used as mobile phases. The effects of organic mobile-phase modifier concentration, temperature, and compound structure were examined. Baseline separation (R_S > 1.5) was readily obtained for many of the compounds.