Sonic hedgehog relates to colorectal carcinogenesis
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- 作者：Kozo Yoshikawa ; Mitsuo Shimada ; Hidenori Miyamoto ; Jun Higashijima ; Tomohiko Miyatani ; Masanori Nishioka ; Nobuhiro Kurita ; Takashi Iwata and Hisanori Uehara
- 关键词：Sonic hedgehog pathway ; Colon cancer ; Adenoma ; carcinoma sequence
- 刊名：Journal of Gastroenterology
- 出版时间：November, 2009
- 出版年：2009
- 期刊代码：122_0944-1174
- 类别：med
- 卷：44
- 期：11
- 页码：1113-1117
- 数据来源：sp
摘要
Aim The activation of Hedgehog signaling, which is critical to normal mammalian gastrointestinal development, is implicated in the development of various tumors, including colorectal cancer. In the pancreas, a precursor lesion overexpresses the Sonic hedgehog (Shh) when compared with normal tissue and cancer. The present study was designed to investigate Shh related protein expression in hyperplastic polyps and the adenoma-carcinoma sequence in the colon and rectum.