Effect of fenfluramine on reinstatement of food seeking in female and male rats: implications for the predictive validity of the reinstatement model
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- 作者：Charles L. Pickens (1) pickensc@nida.nih.gov
Carlo Cifani (1)
Brittany M. Navarre (1)
Hila Eichenbaum (1)
Florence R. Theberge (1)
Michael H. Baumann (1)
Donna J. Calu (1)
Yavin Shaham (1) yshaham@intra.nida.nih.gov - 关键词：Animal models – ; Fenfluramine – ; Diet – ; Food self ; administration – ; Predictive validity – ; Reinstatement – ; Relapse – ; Stress
- 刊名：Psychopharmacology
- 出版时间：May 2012
- 出版年：2012
- 期刊代码：189_0033-3158
- 类别：med
- 卷：221
- 期：2
- 页码：341-353
- 数据来源：sp
摘要
Rationale and objectives Relapse to old unhealthy eating habits while dieting is often provoked by stress or acute exposure to palatable foods. We adapted a rat reinstatement model, which is used to study drug relapse, to study mechanisms of relapse to palatable food seeking induced by food-pellet priming (non-contingent exposure to a small amount of food pellets) or injections of yohimbine (an alpha-2 adrenoceptor antagonist that causes stress-like responses in humans and non-humans). Here, we assessed the predictive validity of the food reinstatement model by studying the effects of fenfluramine, a serotonin releaser with known anorectic effects, on reinstatement of food seeking.