The serotonin transporter polymorphism, 5HTTLPR, is associated with a faster response time to sertraline in an elderly population with major depressive disorder
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- 作者：L. Kathryn Durham ; Suzin M. Webb ; Patrice M. Milos ; Cathryn M. Clary and Albert B. Seymour
- 关键词：5HTTLPR ; Genotype ; Sertraline ; Placebo ; Major depressive disorder
- 刊名：Psychopharmacology
- 出版时间：August 2004
- 出版年：2004
- 期刊代码：189_0033-3158
- 类别：med
- 卷：174
- 期：4
- 页码：525-529
- 数据来源：sp
摘要
Rationale A common polymorphism (5HTTLPR) within the promoter region of the serotonin transporter gene (LSC6A4) has been shown to influence response time as well as overall response to selective serotonin reuptake inhibitors (SSRIs) in subjects with major depressive disorder. We hypothesized that a similar effect in response time to sertraline would be observed and that no effect on response time would be seen in a placebo arm.