Genome-wide Analysis of the Expression Profile of Saccharomyces cerevisiae in Response to Treatment with the Plant Isoflavone, Wighteone, as a Potential Antifungal Agent
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- 作者：Hongying Yin ; Yongchao Zhao ; Yan Zhang ; Hongwu Zhang ; Lizhen Xu ; Zhongmei Zou ; Weiping Yang ; Jing Cheng and Yuxiang Zhou
- 关键词：antifungal ; microarray ; plant extract ; Saccharomyces cerevisiae ; wighteone
- 刊名：Biotechnology Letters
- 出版时间：January 2006
- 出版年：2006
- 期刊代码：6_01415492
- 类别：en
- 卷：28
- 期：2
- 页码：99-105
- 数据来源：sp
摘要
The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. The antifungal activity of the natural products of a series of plants was evaluated and wighteone, 5, 7, 4′–trihydroxy–6–(γ,γ-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 μg/ml). Transcriptome profiling of wighteone-treated S. cerevisiae indicated that wighteone is different from commonly used antifungal compounds in its mode of action.