利用近红外光谱法建立大黄药材一致性检验模型
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摘要
目的:建立大黄药材的一致性检验模型,准确快速地对伪品进行鉴别。方法:收集不同来源的大黄及其伪品23批,利用近红外光谱仪采集其近红外光谱,结合OPUS软件,建立一致性鉴别模型。结果:16批次的大黄均在模型设定CI限度范围内,而7批次的伪品均在模型设定CI限度范围外。结论:建立的一致性检验模型能快速、准确地鉴别大黄,并可以有效地应用于药品快检车筛查。
Objective: To establish the consistency test model for rhubarb,and identify the counterfeit accurately and quickly.Methods: Totally 23 batches of rhubarb and its artifacts from different sources were collected. The near infrared spectroscopy was collected by a near infrared spectrometer,and a consistency identification model was established by combining with OPUS software. Results: Totally 16 batches of rhubarb were within the ranges of CI limits,while the 7 batches of counterfeit products were all outside the ranges of CI limits. Conclusion: The consistency test model can quickly and accurately identify rhubarb,and can be effectively applied in the screening of drug testing vehicles.
Objective: To establish the consistency test model for rhubarb,and identify the counterfeit accurately and quickly.Methods: Totally 23 batches of rhubarb and its artifacts from different sources were collected. The near infrared spectroscopy was collected by a near infrared spectrometer,and a consistency identification model was established by combining with OPUS software. Results: Totally 16 batches of rhubarb were within the ranges of CI limits,while the 7 batches of counterfeit products were all outside the ranges of CI limits. Conclusion: The consistency test model can quickly and accurately identify rhubarb,and can be effectively applied in the screening of drug testing vehicles.
引文
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2 中国药典[S].2015年版.一部.23
3 刘婵,王珺.四川松潘地产大黄药材近红外光谱法快速鉴别研究[J].安徽卫生职业技术学院年报,2015,14(2):73-75
4 刘家水,梁欣健,张丹雁.近红外光谱技术在中药鉴定中的应用[J].广东药学院学报,2011,6(3):27
5 刘建学.实用近红外光谱分析技术[M].北京:科学出版社,2008:115
6武洋,杨永刚,王跃卿,等.近红外一致性检验模型快速鉴别拉米夫定片[J].中国药师,2013,16(9):1437-1439
7 戴震,胡小崧.甲钴胺片近红外一致性检验模型的建立[J].中国药物评价,2017,34(2):95-96
8 李小峰.近红外光谱法对利可君片建立一致性检验模型的应用[J].临床合理用药,2014,7(12):80
9 解朝霞,吴迪,沈丽娟.近红外光谱一致性检验方法对盐酸雷尼替丁胶囊的快速检测[J].中国药物经济学,2014,(4):20-21