MPV、PDW、RDW与冠心病的相关性研究
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摘要
目的:分析冠心病患者平均血小板体积(MPV)、血小板分布宽度(PDW)和红细胞分布宽度(RDW)与冠状动脉(冠脉)病变严重程度的关系,并探讨其预测冠心病的截点值。方法:入选行冠脉造影术及生化指标检测的患者345例,探究MPV、PDW和RDW与冠心病的相关性,并分析上述3项指标与Gensini积分的关系,绘制预测冠心病的ROC曲线。结果:①冠心病组MPV、PDW及RDW水平均显著高于对照组(均P<0.01);②冠心病组MPV、PDW及RDW水平与冠脉Gensini积分呈正相关性;③多因素Logistic回归分析显示,MPV、PDW和RDW为冠心病发生的危险因素;④ROC曲线结果显示,MPV、PDW及RDW预测冠心病的截点值依次为9.53fl、12.12%及12.28%。结论:MPV、PDW及RDW水平与冠脉病变程度呈正相关,其预测冠脉病变程度具有一定的前景。
Objective:To analyze the correlation between mean platelet volume(MPV),platelet distribution width(PDW)and red blood cell distribution width(RDW)and the severity of coronary artery disease in patients with coronary heart disease(CHD),and to explore the cut-off point for predicting CHD.Method:A total of 345 patients who underwent coronary angiography and biochemical detection were enrolled to investigate the correlation between MPV,PDW,RDW and CHD.The relationship between these three indicators and Gensini score was analyzed,and ROC analysis was performed to evaluate the predicting value of MPV,PDW and RDW for CHD.Result:①Levels of MPV,PDW and RDW in CHD group were significantly higher than those in control group(all P<0.01).②There were positive correlations between MPV,PDW,RDW and Gensini score in CHD group.③Multivariate logistic regression analysis showed that MPV,PDW and RDW were risk factors of CHD.④ROC analysis indicated that the cut-off points of MPV,PDW and RDW for predicting CHD were 9.53 fl,12.12%and 12.28%respectively.Conclusion:MPV,PDW and RDW are positively correlated with the severity of coronary lesion,which has a certain prospect in predicting the degree of coronary artery disease.
Objective:To analyze the correlation between mean platelet volume(MPV),platelet distribution width(PDW)and red blood cell distribution width(RDW)and the severity of coronary artery disease in patients with coronary heart disease(CHD),and to explore the cut-off point for predicting CHD.Method:A total of 345 patients who underwent coronary angiography and biochemical detection were enrolled to investigate the correlation between MPV,PDW,RDW and CHD.The relationship between these three indicators and Gensini score was analyzed,and ROC analysis was performed to evaluate the predicting value of MPV,PDW and RDW for CHD.Result:①Levels of MPV,PDW and RDW in CHD group were significantly higher than those in control group(all P<0.01).②There were positive correlations between MPV,PDW,RDW and Gensini score in CHD group.③Multivariate logistic regression analysis showed that MPV,PDW and RDW were risk factors of CHD.④ROC analysis indicated that the cut-off points of MPV,PDW and RDW for predicting CHD were 9.53 fl,12.12%and 12.28%respectively.Conclusion:MPV,PDW and RDW are positively correlated with the severity of coronary lesion,which has a certain prospect in predicting the degree of coronary artery disease.
引文
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[18]艾力,赵宇新,曾玲丽,等.平均血小板体积与冠状动脉SYNTAX评分相关性分析[J].中国动脉硬化杂志,2015,23(3):295-298.
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[20]丁亮亮,邱梅,孙林.平均血小板体积水平与冠心病关系的meta分析[J].中国卫生统计,2016,33(6):1020-1023.
[21]秦文沛,杨毅宁,李晓梅,等.平均血小板体积和Gensini积分预测ST段抬高型心肌梗死患者急诊介入治疗后近期预后的价值[J].中华心血管病杂志,2015,43(1):22-25.
[22]Zalawadiya SK,Veeranna V,Niraj A,et al.Red cell distribution width and risk of coronary heart disease events[J].Am J Cardiol,2010,106(7):988-993.
[2]Yilmaz M,Da4li MN,Uku,et al.Focusing on a complete blood cell parameter:mean platelet volume levels may be a predictor of coronary slow flow[J].Vasc Health Risk Manag,2017,13:255-261.
[3]陈羽乔,叶飞.超敏C反应蛋白与冠状动脉内薄纤维帽粥样斑块相关性研究进展[J].临床心血管病杂志,2017,33(8):773-777.
[4]Murat SN,Duran M,Kalay N,et al.Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes[J].Angiology,2013,64(2):131-136.
[5]Ozlu MF,Ozturk S,Ayhan SS,et al.Predictive value of mean platelet volume in young patients with nonST-segment elevation acute coronary syndromes:a retrospective observational study[J].Anadolu Kardiyol Derg,2013,13(1):57-61.
[6]Dogan A,Aksoy F,Icli A,et al.Mean platelet volume is associated with culprit lesion severity and cardiac events in acute coronary syndromes without ST elevation[J].Blood Coagul Fibrinolysis,2012,23(4):324-330.
[7]Demir S,Avsar MK,Karakaya Z,et al.Increased mean platelet volume is associated with coronary artery ectasia[J].Postepy Kardiol Interwencyjnej,2013,9(3):241-245.
[8]闫双冰,李菊香,程晓曙.脂蛋白(a)与心血管疾病的研究进展[J].临床心血管病杂志,2018,34(3):213-217.
[9]Bekler A,Ozkan MT,Tenekecioglu E,et a1.Increased platelet distribution width is associated with severity of coronary artery disease in patients with acute coronary syndrome[J].Angiology,2015,66(7):638-643.
[10]Akin F,Ayca B,Kose N,et a1.Relation of platelet indices to seventy of coronary artery disease in patients undergoing primary percutaneous coronary intervention[J].Perfusion,2016,31(3):216-222.
[11]Sahin DY,Gur M,Elbasan Z,et al.Mean platelet volume and extent and complexity of coronary artery disease in diabetic and nondiabetic patients with ST elevation myocardial infarction[J].Angiology,2013,64(7):505-511.
[12]朱丽丽,梁婷,赵婷,等.急性冠状动脉综合征患者血清中介素水平及其临床意义[J].临床心血管病杂志,2016,32(3):265-268.
[13]Akin F,Kose N,Ayca B,et a1.Relation between red cell distribution width and severity of coronary artery disease in patients with acute myocardial infarction[J].Angiology,2013,64(8):592-596.
[14]黄卓山,钟钧琳,罗艳婷,等.冠心病患者LDL-C/HDL-C比值与冠脉病变严重程度的相关性[J].中山大学学报(医学版),2018,39(2):303-308.
[15]李超,彭瑜,高涵翔,等.血浆中性粒细胞明胶酶相关脂质运载蛋白水平与急性ST段抬高型心肌梗死病变严重程度的关系[J].中国循环杂志,2018,33(3):222-226.
[16]王白石,李东阳,陈兴国,等.游离脂肪酸与冠心病患者冠脉病变严重程度的相关性[J].中国老年学杂志,2017,37(6):1352-1354.
[17]姚云婕,钱雪松,盛宇峰.老年冠心病患者外周血同型半胱氨酸及尿酸水平与冠脉病变程度的相关性[J].中国老年学杂志,2016,36(23):5871-5873.
[18]艾力,赵宇新,曾玲丽,等.平均血小板体积与冠状动脉SYNTAX评分相关性分析[J].中国动脉硬化杂志,2015,23(3):295-298.
[19]任洁,马宾,王明霞,等.血小板参数与冠心病患者冠状动脉病变程度相关性研究[J].中国循证心血管医学杂志,2014,6(6):714-716.
[20]丁亮亮,邱梅,孙林.平均血小板体积水平与冠心病关系的meta分析[J].中国卫生统计,2016,33(6):1020-1023.
[21]秦文沛,杨毅宁,李晓梅,等.平均血小板体积和Gensini积分预测ST段抬高型心肌梗死患者急诊介入治疗后近期预后的价值[J].中华心血管病杂志,2015,43(1):22-25.
[22]Zalawadiya SK,Veeranna V,Niraj A,et al.Red cell distribution width and risk of coronary heart disease events[J].Am J Cardiol,2010,106(7):988-993.