壳聚糖季铵盐的抗菌性能及医用研究进展
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摘要
壳聚糖季铵盐是一种壳聚糖季铵化产物,来源丰富,具有无毒、抗菌、抗凝、促愈等性能。本文综述了壳聚糖季铵盐的抗菌性能及其在医药领域应用的进展情况,并展望其研究趋势。
Chitosan quaternary ammonium salt is a kind of chitosan Quaternate product,which is rich in nature,and has the properties of non-toxic,harmless,antibacterial,anticoagulant and so on. In this paper,the antibacterial properties of chitosan quaternary ammonium salt and its application in the field of medicine are reviewed,and the trend of its research is also prospected.
Chitosan quaternary ammonium salt is a kind of chitosan Quaternate product,which is rich in nature,and has the properties of non-toxic,harmless,antibacterial,anticoagulant and so on. In this paper,the antibacterial properties of chitosan quaternary ammonium salt and its application in the field of medicine are reviewed,and the trend of its research is also prospected.
引文
[1]Yang Tsui-chu,Chou Cheng-chun,Li Chen-fang.[J].International Journal of Food Microbiology,2005,97(3):237-245.
[2]Rhim J W,Hong S I,Park H M,et al.[J].Journal of Agriculture and Food Chemistry,2006,54(16):5814-5822.
[3]黎剑辉,庄少玲,刘长坤,等.壳聚糖及壳聚糖季铵盐的应用研究进展[J].中国食剂,2015,(06):167-172.
[4]刑其毅.基础有机化学下册[M].3版.北京:高等教育出版社,2005.
[5]Zivanovic S,Li J,Davidson P M,et al.[J].Biomacromolecules,2007,8(5):1505-1510.
[6]Kim C H,Choi J W,Chun H J,et al.Synthesis of chitosan and derivatives and quaternary ammonium salt and their antibacterial activity[J].Polymer Bulletin,1997(38):387-393.
[7]彭霏,蔺丽,方能虎.碘化钾催化合成2,3-环氧丙基三甲基氯化铵的研究[J].现代化工,2010,(30):66-67.
[8]许晨,卢灿辉,丁马太.壳聚糖季铵盐的合成及结构表征[J].功能高分子学报,1997,10(1):52-55.
[9]王凤菊,陈煜,谭惠民.壳聚糖季铵盐抗菌剂的研究进展[J].化工新型材料,2011,39(11):13-15.
[10]Namcw Kimyh Kosw.Modificationofpolyacrylonitrile(PAN)fiberbyblendingwith N-(2-hydroxy)propyl-3-trimethyl ammoniumchitosanchloride[J].Journal of Applied Polymer Science,1999,74(9):2258-2265.
[11]Mifl,Shyus Shenctetal.Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine:Preparation of antigen-adsorbed microsphere and invitrorelease[J].Biomaterials,1999,20(17):1603-1612.
[12]吴迪,蔡伟民.壳聚糖季铵盐的抑菌机理研究[J].哈尔滨工业大学学报,2005,37(7):1014-1018.
[13]李淑荣.壳聚糖季铵盐衍生物抗菌机理的初步研究[J].信阳师范学院学报(自然科学版),2008,21(04):509-511.
[14]刘振儒,赵江霞.水溶性壳聚糖季铵盐的抗菌性能[J].青岛科技大学学报,2006,27(4):317-319.
[15]刘鹏涛,马滢,司传领,等.壳聚糖季铵盐的合成及其体外抗菌活性研究[J].功能材料,2009,(40):670-672.
[16]程国君,陈水平,吴国忠,等.低相对分子质量壳聚糖季铵盐的制备及抗菌性能研究[J].辐射研究与辐射工艺学报,2007,25(3):137-140.
[17]李世迁,姚评佳.羧甲基壳聚糖季铵盐的制备及其抑菌性能研究[J].桂教科研,2006,(11):22-24.
[18]赵希荣,夏文水.二元取代壳聚糖季铵盐的抗菌活性[J].食品与生物技术学报,2006,25(5):55-65.
[19]王冰,金朝霞,张宗申.复合型季铵盐类抗菌剂的抑菌效果[J].大连工业大学学报,2015,34(01):20-23.
[20]张静,中西医综合治疗病理性瘢痕的临床应用研究[D].广州中医药大学,2017.
[21]鲁旺旺.壳聚糖护肤液在皮肤瘢痕修复中的应用研究[J].科技风,2017(11):261.
[22]汪玉庭,刘玉红,张淑琴.甲壳素、壳聚糖的化学改性及其衍生物应用研究进展[J].功能高分子学报,2002,15(1):107-114.
[23]LIANG Xiao-Fei,HU Jing-Ying,CHEN Fu-Hua,et a1.Characte rization of Chitosan Polymeric Ethosomes Capable of Encapsulating Hydrophobic and Hydrophilic Drugs Prepared by a Microemulsion Method[J].Wuli Huaxue Xuebao,2012,28(4):897-902.
[24]郭东华,黄赫坤,柏亚林,等.碘化壳聚糖季铵盐的急性毒性及降脂作用实验研究[J].中国药房,2009,20(34):2655-2657.
[25]黄瑞华,杨炳超,郑东升,等.壳聚糖季铵盐的制备及应用进展[J].化工时刊,2010,24(10):41-45.
[26]阳元娥,罗发兴.壳聚糖及其衍生物在医药上的应用[J].上海生物医学工程,2001,22(3):41-44.
[27]张建国,任慧霞,刘其凤,等.低分子壳聚糖季铵盐对小鼠实体瘤及其免疫系统的影响[J].中国生化药物杂志,2005,26(2):93-95.
[28]吕键,刘立春,池善女,等.甲壳素、壳聚糖及其衍生物在医药领域的应用[J].延边大学学报(自然科学版),2003,29(4):261-266.
[30]姚云真,黄雅钦.壳聚糖季铵盐/明胶共混抗菌膜的性能研究[J].明胶科学与技术,2016,36(03):146-153.
[31]张浩,王大丽,周绪雷,等.壳聚糖季铵盐生物胶体液在修复皮肤软组织缺损中的应用[J].黑龙江医药科学,2017,40(01):34-35.
[32]李红艳,丁利营.壳聚糖季按盐珪凝胶治疗增生性癒痕的临床观察[J].中国美容医学,2014,(21):1810-1812.
[33]屠美,崔莹,周长忍,等.肝素化壳聚糖季铵盐/壳聚糖复合膜抗凝血性能的研究[J].功能高分子学报,1997,(03):44-48.
[34]王浩.壳聚糖及其衍生物在医药领域的应用研究进展[J].发酵科技通讯,2015,44(01):58-61.
[2]Rhim J W,Hong S I,Park H M,et al.[J].Journal of Agriculture and Food Chemistry,2006,54(16):5814-5822.
[3]黎剑辉,庄少玲,刘长坤,等.壳聚糖及壳聚糖季铵盐的应用研究进展[J].中国食剂,2015,(06):167-172.
[4]刑其毅.基础有机化学下册[M].3版.北京:高等教育出版社,2005.
[5]Zivanovic S,Li J,Davidson P M,et al.[J].Biomacromolecules,2007,8(5):1505-1510.
[6]Kim C H,Choi J W,Chun H J,et al.Synthesis of chitosan and derivatives and quaternary ammonium salt and their antibacterial activity[J].Polymer Bulletin,1997(38):387-393.
[7]彭霏,蔺丽,方能虎.碘化钾催化合成2,3-环氧丙基三甲基氯化铵的研究[J].现代化工,2010,(30):66-67.
[8]许晨,卢灿辉,丁马太.壳聚糖季铵盐的合成及结构表征[J].功能高分子学报,1997,10(1):52-55.
[9]王凤菊,陈煜,谭惠民.壳聚糖季铵盐抗菌剂的研究进展[J].化工新型材料,2011,39(11):13-15.
[10]Namcw Kimyh Kosw.Modificationofpolyacrylonitrile(PAN)fiberbyblendingwith N-(2-hydroxy)propyl-3-trimethyl ammoniumchitosanchloride[J].Journal of Applied Polymer Science,1999,74(9):2258-2265.
[11]Mifl,Shyus Shenctetal.Porous chitosan microsphere for controlling the antigen release of Newcastle disease vaccine:Preparation of antigen-adsorbed microsphere and invitrorelease[J].Biomaterials,1999,20(17):1603-1612.
[12]吴迪,蔡伟民.壳聚糖季铵盐的抑菌机理研究[J].哈尔滨工业大学学报,2005,37(7):1014-1018.
[13]李淑荣.壳聚糖季铵盐衍生物抗菌机理的初步研究[J].信阳师范学院学报(自然科学版),2008,21(04):509-511.
[14]刘振儒,赵江霞.水溶性壳聚糖季铵盐的抗菌性能[J].青岛科技大学学报,2006,27(4):317-319.
[15]刘鹏涛,马滢,司传领,等.壳聚糖季铵盐的合成及其体外抗菌活性研究[J].功能材料,2009,(40):670-672.
[16]程国君,陈水平,吴国忠,等.低相对分子质量壳聚糖季铵盐的制备及抗菌性能研究[J].辐射研究与辐射工艺学报,2007,25(3):137-140.
[17]李世迁,姚评佳.羧甲基壳聚糖季铵盐的制备及其抑菌性能研究[J].桂教科研,2006,(11):22-24.
[18]赵希荣,夏文水.二元取代壳聚糖季铵盐的抗菌活性[J].食品与生物技术学报,2006,25(5):55-65.
[19]王冰,金朝霞,张宗申.复合型季铵盐类抗菌剂的抑菌效果[J].大连工业大学学报,2015,34(01):20-23.
[20]张静,中西医综合治疗病理性瘢痕的临床应用研究[D].广州中医药大学,2017.
[21]鲁旺旺.壳聚糖护肤液在皮肤瘢痕修复中的应用研究[J].科技风,2017(11):261.
[22]汪玉庭,刘玉红,张淑琴.甲壳素、壳聚糖的化学改性及其衍生物应用研究进展[J].功能高分子学报,2002,15(1):107-114.
[23]LIANG Xiao-Fei,HU Jing-Ying,CHEN Fu-Hua,et a1.Characte rization of Chitosan Polymeric Ethosomes Capable of Encapsulating Hydrophobic and Hydrophilic Drugs Prepared by a Microemulsion Method[J].Wuli Huaxue Xuebao,2012,28(4):897-902.
[24]郭东华,黄赫坤,柏亚林,等.碘化壳聚糖季铵盐的急性毒性及降脂作用实验研究[J].中国药房,2009,20(34):2655-2657.
[25]黄瑞华,杨炳超,郑东升,等.壳聚糖季铵盐的制备及应用进展[J].化工时刊,2010,24(10):41-45.
[26]阳元娥,罗发兴.壳聚糖及其衍生物在医药上的应用[J].上海生物医学工程,2001,22(3):41-44.
[27]张建国,任慧霞,刘其凤,等.低分子壳聚糖季铵盐对小鼠实体瘤及其免疫系统的影响[J].中国生化药物杂志,2005,26(2):93-95.
[28]吕键,刘立春,池善女,等.甲壳素、壳聚糖及其衍生物在医药领域的应用[J].延边大学学报(自然科学版),2003,29(4):261-266.
[30]姚云真,黄雅钦.壳聚糖季铵盐/明胶共混抗菌膜的性能研究[J].明胶科学与技术,2016,36(03):146-153.
[31]张浩,王大丽,周绪雷,等.壳聚糖季铵盐生物胶体液在修复皮肤软组织缺损中的应用[J].黑龙江医药科学,2017,40(01):34-35.
[32]李红艳,丁利营.壳聚糖季按盐珪凝胶治疗增生性癒痕的临床观察[J].中国美容医学,2014,(21):1810-1812.
[33]屠美,崔莹,周长忍,等.肝素化壳聚糖季铵盐/壳聚糖复合膜抗凝血性能的研究[J].功能高分子学报,1997,(03):44-48.
[34]王浩.壳聚糖及其衍生物在医药领域的应用研究进展[J].发酵科技通讯,2015,44(01):58-61.