银杏内酯N水溶性磺丁基-β-环糊精包合物的研究
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摘要
目的研究水溶性磺丁基-β-环糊精(SBE-β-CD)对银杏内酯N(GN)的包合作用。方法采用饱和水溶液法制备GN/SBE-β-CD包合物,通过差示扫描量热法(DSC)、X-射线衍射法(XRD)和红外光谱法(IR)对包合物进行鉴定,并测定包合物的稳定常数。结果 GN/SBE-β-CD包合物稳定,溶解度提高了106倍,表观稳定常数Kc随着温度的升高而升高。结论 SBE-β-CD可与GN形成稳定的包合物。
Objective To investigate the complex of ginkgolide N(GN)with sulfobutylether-β-cyclodextrin(SBE-β-CD).Methods The inclusion complex was prepared by solution stirring method and was confirmed by DSC,X-ray diffraction and IR.The complex constants were also studied.Results The inclusion complex of GN/SBE-β-CD was prepared successfully and the solubility of GN was enhanced by 106 times.The apparent complex constant Kc was increased when the temperature was increased.Conclusion SBE-β-CD is an ideal solubilizer for poorly water soluble drugs.
Objective To investigate the complex of ginkgolide N(GN)with sulfobutylether-β-cyclodextrin(SBE-β-CD).Methods The inclusion complex was prepared by solution stirring method and was confirmed by DSC,X-ray diffraction and IR.The complex constants were also studied.Results The inclusion complex of GN/SBE-β-CD was prepared successfully and the solubility of GN was enhanced by 106 times.The apparent complex constant Kc was increased when the temperature was increased.Conclusion SBE-β-CD is an ideal solubilizer for poorly water soluble drugs.
引文
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[17]佟若菲,林宏,李维超,等.HPLC-MS法测定银杏叶片中银杏内酯A、B、C和白果内酯[J].现代药物与临床,2017,32(3):386-389.
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[3]谢捷,杜君琛,朱兴一,等.磺丁基醚-β-环糊精对葛根素的增溶作用及其包合物的研制[J].中成药,2012,34(3):454-458.
[4]潘雪梅,房德敏.羟丙基-β-环糊精和磺丁基醚-β-环糊精应用进展[J].天津药学,2005,17(5):59-61.
[5]程弘夏,刘晖,陈伟,等.多烯紫杉醇磺丁基醚-β-环糊精包合物的增溶作用及制备[J].中国医院药学杂志,2010,30(18):1541-1545.
[6]谷福根,高永良,崔福德.磺丁基醚-β-环糊精及其在药剂学中的应用[J].中国新药杂志,2004,13(1):15-19.
[7]曹雅培,王静,曹德英.药用辅料磺丁基醚-β-环糊精在不同制剂中的应用进展[J].中国药房,2012,23(1):79-82.
[8]刘红霞,陈志恒,孙世光.银杏内酯注射液临床使用合理性与安全性再评价研究[J].中国临床药理学杂志,2016,32(10):930-932.
[9]刘娜,史艳秋,林晓冬,等.银杏内酯B注射液抗血淤作用的研究[J].中药材,2017,40(3):696-699.
[10]黄贱英,孙建宁,梅世昌,等.银杏内酯B对缺血/再灌脑损伤大鼠的保护作用[J].中国药理学通报,2008,24(2):269-272.
[11]王钊,王欣,杨静,等.磺丁基-β-环糊精与齐墩果酸的热力学稳定性研究[J].中国药师,2013,16(5):635-638.
[12]冯彩霞,修宪,李晨晓,等.磺丁基醚-β-环糊精和羟丙基-β-环糊精对普拉格雷增溶作用的考察[J].中国药学杂志,2014,49(14):1240-1242.
[13]张苗苗,张鑫,王云霞,等.UPLC法测定银杏叶茶中总黄酮醇苷的含量[J].西北药学杂志,2017,32(1):28-31.
[14]秦建平,吴建雄,潘有智,等.HPLC-ELSD法测定白果中银杏内酯A、银杏内酯B和银杏内酯C[J].现代药物与临床,2016,31(2):155-157.
[15]Higuchi T,Connors K A.Phase-solubility techniques[J].Adv Anal Chem Instrum,1965,(4):117-212.
[16]龚欢,丁存刚,李周,等.SD大鼠体内各组织中银杏内酯B的LC-MS/MS测定[J].中国医药工业杂志,2017,48(4):543-548.
[17]佟若菲,林宏,李维超,等.HPLC-MS法测定银杏叶片中银杏内酯A、B、C和白果内酯[J].现代药物与临床,2017,32(3):386-389.
[18]王猛,乔红群,严拯宇.多西他赛磺丁基-β-环糊精包合物的大鼠药代动力学[J].中国药科大学学报,2013,44(2):156-160
[19]杜琳,赵凌志,周毓麟,等.新型银杏叶内酯微球的制备工艺研究[J].长春中医药大学学报,2017,33(2):218-220.