摘要
目的评价补充铁剂联合根除幽门螺杆菌(Hp)治疗(联合治疗)对缺铁性贫血合并Hp感染患者的效果。方法检索中国学术期刊网络出版总库、维普中文科技期刊数据库、万方中国学术期刊数据库、PubMed、Embase和Cochrane Library等中英文数据库,查找关于联合治疗与单用铁剂治疗对缺铁性贫血合并Hp感染患者效果比较的文献,发表时间为2000—2018年。采用均数差(WMD)或标准化均数差(SMD)评估治疗前后血红蛋白、血清铁和铁蛋白指标变化。结果搜索到1 908篇文献,最终纳入12篇随机对照试验(RCT)研究文献,包括790例缺铁性贫血合并Hp感染患者,联合治疗组和单用铁剂治疗组各395例。联合治疗组患者治疗后血红蛋白水平(WMD=13.38,95%CI:9.40~17.37)、血清铁水平(WMD=5.31,95%CI:3.92~6.69)和铁蛋白水平(SMD=1.84,95%CI:1.01~2.67)均高于单用铁剂治疗组。结论对于缺铁性贫血合并Hp感染患者,补充铁剂联合根除Hp治疗效果明显优于单用铁剂治疗。
引文
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