环状RNA与肿瘤关系研究进展
|
摘要
环状RNA(circular RNA,circRNA)是一种广泛存在于真核生物的非编码RNA,具有丰度高、结构稳定、高度保守及组织特异表达等性质。circRNA可作为微小RNA海绵、基因转录和表达的调控因子、RNA结合蛋白等,可能通过基因调控等功能与肿瘤发生、发展密切相关。本文就circRNA的起源、性质、功能及其与肿瘤关系的研究进展作一综述。
Circular RNA(circRNA)is a kind of non-coding RNA that widely exists in eukaryote,with the characteristics of high abundance,stable structure,highly conservative property and tissue-specific expression.Being an miRNA sponge,regulatory factor of transcription and expression and RNA binding protein,circRNA is closely correlated with the development and progression of tumors by gene regulation.This paper reviews the research progress of the circRNA origin,property,function and relationship with tumors.
Circular RNA(circRNA)is a kind of non-coding RNA that widely exists in eukaryote,with the characteristics of high abundance,stable structure,highly conservative property and tissue-specific expression.Being an miRNA sponge,regulatory factor of transcription and expression and RNA binding protein,circRNA is closely correlated with the development and progression of tumors by gene regulation.This paper reviews the research progress of the circRNA origin,property,function and relationship with tumors.
引文
[1] HAN C,SEEBACHER N A, HORNICEK F J,et al.Regulation of microRNAs function by circular RNAs in human cancer[J].Oncotarget,2017,8(38):64622-64637.
[2] SALZMAN J,GAWAD C,WANG P L,et al.Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types[J].PLoS One,2012,7(2):e30733.
[3]WILUSZ J E,SHARP P A.Molecular biology:a circuitous route to noncoding RNA[J].Science,2013,340(6131):440-441.
[4] LYU D,HUANG S.The emerging role and clinical implication of human exonic circular RNA[J].RNA Biol,2017,14(8):1000-1006.
[5] WANG F,NAZARALI A J,JI S.Circular RNAs as potential biomarkers for cancer diagnosis and therapy[J].Am J Cancer Res,2016,6(6):1167-1176.
[6] JECK W R,SORRENTINO J A,WANG K,et al.Circular RNAs are abundant,conserved,and associated with ALU repeats[J].RNA,2013,19(2):141-157.
[7] LI Z,HUANG C,BAO C,et al.Corrigendum:exon-intron circular RNAs regulate transcription in the nucleus[J].Nat Struct Mol Biol,2017,24(2):194.
[8] CONN S J,PILLMAN K A,TOUBIA J,et al.The RNA binding protein quaking regulates formation of circRNAs[J].Cell,2015,160(6):1125-1134.
[9] ASHWAL-FLUSS R,MEYER M,PAMUDURTI N R,et al.circRNA biogenesis competes with pre-mRNA splicing[J].Mol Cell,2014,56(1):55-66.
[10] JECK W R,SHARPLESS N E.Detecting and characterizing circular RNAs[J].Nat Biotechnol,2014,32(5):453-461.
[11] WANG P L,BAO Y,YEE M C,et al.Circular RNA is expressed across the eukaryotic tree of life[J].PLoS One,2014,9(6):e90859.
[12] MEMCZAK S,JENS M,ELEFSINIOTI A,et al.Circular RNAs are a large class of animal RNAs with regulatory potency[J].Nature,2013,495(7441):333-338.
[13] QU S,YANG X,LI X,et al.Circular RNA:a new star of noncoding RNAs[J].Cancer Lett,2015,365(2):141-148.
[14] RYBAK-WOLF A,STOTTMEISTER C,GLAZAR P,et al.Circular RNAs in the mammalian brain are highly abundant,conserved,and dynamically expressed[J].Mol Cell,2015,58(5):870-885.
[15] HANSEN T B,JENSEN T I,CLAUSEN B H,et al.Natural RNA circles function as efficient microRNA sponges[J].Nature,2013,495(7441):384-388.
[16] HAN Y N,XIA S Q,ZHANG Y Y,et al.Circular RNAs:a novel type of biomarker and genetic tools in cancer[J].Oncotarget,2017,8(38):64551-64563.
[17]刘薇,郭万刚,郑强荪,等.RNA结合蛋白QKI在心肌肥大中的作用[J].中华实用诊断与治疗杂志,2012,26(9):841-843.
[18] DUDEKULA D B,PANDA A C,GRAMMATIKAKIS I,et al.CircInteractome:a web tool for exploring circular RNAs and their interacting proteins and microRNAs[J].RNA Biol,2016,13(1):34-42.
[19] BEGUM S,YIU A,STEBBING J,et al.Novel tumour suppressive protein encoded by circular RNA,circ-SHPRH,in glioblastomas[J].Oncogene,2018,37(30):4055-4057.
[20] CHEN X, HAN P, ZHOU T,et al.circRNADb:a comprehensive database for human circular RNAs with proteincoding annotations[J].Sci Rep,2016,6:34985.
[21] YANG Y,FAN X,MAO M,et al.Extensive translation of circular RNAs driven by N6-methyladenosine[J].Cell Res,2017,27(5):626-641.
[22] YANG W,DU W W,LI X,et al.FOXO3activity promoted by non-coding effects of circular RNA and FOXO3pseudogene in the inhibition of tumor growth and angiogenesis[J].Oncogene,2016,35(30):3919-3931.
[23] GHOSAL S, DAS S, SEN R, et al. Circ2Traits:a comprehensive database for circular RNA potentially associated with disease and traits[J].Front Genet,2013,4:283.
[24]郭雷鸣,丁高峰,葛红,等.放疗联合EGFR-TKI治疗非小细胞肺癌EGFR-TKI治疗后新发骨转移疗效观察[J].中华实用诊断与治疗杂志,2017,31(11):1112-1114.
[25] MA X,YANG X,BAO W,et al.Circular RNA circMAN2B2facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1axis[J].Biochem Biophys Res Commun,2018,498(4):1009-1015.
[26] BAK R O,HOLLENSEN A K,MIKKELSEN J G.Managing microRNAs with vector-encoded decoy-type inhibitors[J].Mol Ther,2013,21(8):1478-1485.
[27] WANG J,LI X,LU L,et al.Circular RNA HSA_circ_0000567can be used as a promising diagnostic biomarker for human colorectal cancer[J].J Clin Lab Anal,2018,32(5):e22379.
[28] YANG F,LIU D Y,GUO J T,et al.Circular RNA circLDLRAD3as a biomarker in diagnosis of pancreatic cancer[J].World J Gastroenterol,2017,23(47):8345-8354.
[2] SALZMAN J,GAWAD C,WANG P L,et al.Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types[J].PLoS One,2012,7(2):e30733.
[3]WILUSZ J E,SHARP P A.Molecular biology:a circuitous route to noncoding RNA[J].Science,2013,340(6131):440-441.
[4] LYU D,HUANG S.The emerging role and clinical implication of human exonic circular RNA[J].RNA Biol,2017,14(8):1000-1006.
[5] WANG F,NAZARALI A J,JI S.Circular RNAs as potential biomarkers for cancer diagnosis and therapy[J].Am J Cancer Res,2016,6(6):1167-1176.
[6] JECK W R,SORRENTINO J A,WANG K,et al.Circular RNAs are abundant,conserved,and associated with ALU repeats[J].RNA,2013,19(2):141-157.
[7] LI Z,HUANG C,BAO C,et al.Corrigendum:exon-intron circular RNAs regulate transcription in the nucleus[J].Nat Struct Mol Biol,2017,24(2):194.
[8] CONN S J,PILLMAN K A,TOUBIA J,et al.The RNA binding protein quaking regulates formation of circRNAs[J].Cell,2015,160(6):1125-1134.
[9] ASHWAL-FLUSS R,MEYER M,PAMUDURTI N R,et al.circRNA biogenesis competes with pre-mRNA splicing[J].Mol Cell,2014,56(1):55-66.
[10] JECK W R,SHARPLESS N E.Detecting and characterizing circular RNAs[J].Nat Biotechnol,2014,32(5):453-461.
[11] WANG P L,BAO Y,YEE M C,et al.Circular RNA is expressed across the eukaryotic tree of life[J].PLoS One,2014,9(6):e90859.
[12] MEMCZAK S,JENS M,ELEFSINIOTI A,et al.Circular RNAs are a large class of animal RNAs with regulatory potency[J].Nature,2013,495(7441):333-338.
[13] QU S,YANG X,LI X,et al.Circular RNA:a new star of noncoding RNAs[J].Cancer Lett,2015,365(2):141-148.
[14] RYBAK-WOLF A,STOTTMEISTER C,GLAZAR P,et al.Circular RNAs in the mammalian brain are highly abundant,conserved,and dynamically expressed[J].Mol Cell,2015,58(5):870-885.
[15] HANSEN T B,JENSEN T I,CLAUSEN B H,et al.Natural RNA circles function as efficient microRNA sponges[J].Nature,2013,495(7441):384-388.
[16] HAN Y N,XIA S Q,ZHANG Y Y,et al.Circular RNAs:a novel type of biomarker and genetic tools in cancer[J].Oncotarget,2017,8(38):64551-64563.
[17]刘薇,郭万刚,郑强荪,等.RNA结合蛋白QKI在心肌肥大中的作用[J].中华实用诊断与治疗杂志,2012,26(9):841-843.
[18] DUDEKULA D B,PANDA A C,GRAMMATIKAKIS I,et al.CircInteractome:a web tool for exploring circular RNAs and their interacting proteins and microRNAs[J].RNA Biol,2016,13(1):34-42.
[19] BEGUM S,YIU A,STEBBING J,et al.Novel tumour suppressive protein encoded by circular RNA,circ-SHPRH,in glioblastomas[J].Oncogene,2018,37(30):4055-4057.
[20] CHEN X, HAN P, ZHOU T,et al.circRNADb:a comprehensive database for human circular RNAs with proteincoding annotations[J].Sci Rep,2016,6:34985.
[21] YANG Y,FAN X,MAO M,et al.Extensive translation of circular RNAs driven by N6-methyladenosine[J].Cell Res,2017,27(5):626-641.
[22] YANG W,DU W W,LI X,et al.FOXO3activity promoted by non-coding effects of circular RNA and FOXO3pseudogene in the inhibition of tumor growth and angiogenesis[J].Oncogene,2016,35(30):3919-3931.
[23] GHOSAL S, DAS S, SEN R, et al. Circ2Traits:a comprehensive database for circular RNA potentially associated with disease and traits[J].Front Genet,2013,4:283.
[24]郭雷鸣,丁高峰,葛红,等.放疗联合EGFR-TKI治疗非小细胞肺癌EGFR-TKI治疗后新发骨转移疗效观察[J].中华实用诊断与治疗杂志,2017,31(11):1112-1114.
[25] MA X,YANG X,BAO W,et al.Circular RNA circMAN2B2facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1axis[J].Biochem Biophys Res Commun,2018,498(4):1009-1015.
[26] BAK R O,HOLLENSEN A K,MIKKELSEN J G.Managing microRNAs with vector-encoded decoy-type inhibitors[J].Mol Ther,2013,21(8):1478-1485.
[27] WANG J,LI X,LU L,et al.Circular RNA HSA_circ_0000567can be used as a promising diagnostic biomarker for human colorectal cancer[J].J Clin Lab Anal,2018,32(5):e22379.
[28] YANG F,LIU D Y,GUO J T,et al.Circular RNA circLDLRAD3as a biomarker in diagnosis of pancreatic cancer[J].World J Gastroenterol,2017,23(47):8345-8354.