庆大霉素辅助局部注射修复眼睑炎性肉芽肿的美容效果及预后观察
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摘要
目的:探讨庆大霉素辅助局部注射修复眼睑炎性肉芽肿的美容效果及预后。方法:回顾性分析笔者医院2015年5月-2018年3月收治的眼睑炎性肉芽肿患者50例的诊疗情况。根据用药方式的不同,分为观察组(n=35)和对照组(n=15)。对照组采用曲安奈德局部注射修复治疗,观察组采用曲安奈德联合庆大霉素局部注射修复治疗。治疗3周后,比较两组患者美容效果、肉芽肿硬度及大小、患者对美观状况的满意度以及不良反应。结果:治疗后,观察组总有效率为88.57%,显著高于对照组的60.00%,差异有统计学意义(P<0.05)。治疗前,两组患者肉芽肿硬度及大小无显著性差异(P>0.05);治疗后,两组患者肉芽肿硬度及大小明显减小,且观察组患者肉芽肿硬度及大小分别为(1.14±0.11)分、(0.22±0.12)cm2,明显小于对照组(1.32±0.25)分、(0.45±0.17)cm2,差异有统计学意义(P<0.05)。观察组患者满意度为85.71%,显著高于对照组53.33%,差异有统计学意义(P<0.05)。结论:眼睑炎性肉芽肿患者采用庆大霉素辅助局部注射修复,可取得较好的美容效果,保证患者美观,提高患者满意度,值得临床推广应用。
Objective To investigate the cosmetic effect and prognosis of gentamicin-assisted granuloma local injection for repairing orbital inflammatory granuloma. Methods Retrospective analysis of the diagnosis and treatment of 50 cases of orbital inflammatory granuloma admitted to our hospital from May 2015 to March 2018. According to the different medication methods, it was divided into the observation group(n=35) and the control group(n=15).The control group was treated with local injection of triamcinolone acetonide, and the observation group was treated with local injection of triamcinolone acetonide combined with gentamicin. After 3 weeks of treatment, the cosmetic effects, granuloma hardness, size, patient satisfaction with aesthetic conditions, and adverse reactions were compared between the two groups. Results After treatment, the total effective rate of the observation group was 88.57%, which was significantly higher than that of the control group(60.00%, P<0.05). Before treatment, there was no significant difference in the hardness and size of granuloma between the two groups(P>0.05). After treatment, the granuloma hardness and size of the two groups were significantly reduced, and the hardness and size of granuloma in the observation group were(1.14±0.11) points,(0.22±0.12)cm2, significantly less than the control group(1.32±0.25) points,(0.45±0.17)cm2, the differences were statistically significant(P<0.05). The patient satisfaction of the observation group was 85.71%, which was significantly higher than that of the control group(53.33%, P<0.05). Conclusion Patients with orbital inflammatory granuloma have achieved significant cosmetic effects by using gentamicin-assisted granuloma local injection repair and repair treatment to ensure the patient's aesthetics and improve patient satisfaction. It is worthy of clinical promotion.
Objective To investigate the cosmetic effect and prognosis of gentamicin-assisted granuloma local injection for repairing orbital inflammatory granuloma. Methods Retrospective analysis of the diagnosis and treatment of 50 cases of orbital inflammatory granuloma admitted to our hospital from May 2015 to March 2018. According to the different medication methods, it was divided into the observation group(n=35) and the control group(n=15).The control group was treated with local injection of triamcinolone acetonide, and the observation group was treated with local injection of triamcinolone acetonide combined with gentamicin. After 3 weeks of treatment, the cosmetic effects, granuloma hardness, size, patient satisfaction with aesthetic conditions, and adverse reactions were compared between the two groups. Results After treatment, the total effective rate of the observation group was 88.57%, which was significantly higher than that of the control group(60.00%, P<0.05). Before treatment, there was no significant difference in the hardness and size of granuloma between the two groups(P>0.05). After treatment, the granuloma hardness and size of the two groups were significantly reduced, and the hardness and size of granuloma in the observation group were(1.14±0.11) points,(0.22±0.12)cm2, significantly less than the control group(1.32±0.25) points,(0.45±0.17)cm2, the differences were statistically significant(P<0.05). The patient satisfaction of the observation group was 85.71%, which was significantly higher than that of the control group(53.33%, P<0.05). Conclusion Patients with orbital inflammatory granuloma have achieved significant cosmetic effects by using gentamicin-assisted granuloma local injection repair and repair treatment to ensure the patient's aesthetics and improve patient satisfaction. It is worthy of clinical promotion.
引文
[1]万云凤,连榕,洪文荣,等.庆大霉素生物合成基因簇中抗性基因gmr B及gmr A的功能研究[J/OL].中国抗生素杂志,2018,43(6):688-695
[2]中华医学会眼科学分会神经眼科学组.我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J].中华眼科杂志,2015,51(5):323-326.
[3]李明,刘少倩,陈碾,等.自体组织再造睑板联合颞区皮瓣修复下眼睑全层缺损[J].中南大学学报(医学版),2017,42(6):662-666.
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[11]庆惠玲,李晓华,张俊鸽,等.眼睑近泪小点肿物切除56例疗效分析[J].眼科新进展,2015,35(2):141-143.
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[13]吴晓蓉,邹晶,邵毅,等.睑板下注射曲安奈德改善活动期春季角结膜炎患者眼表症状的临床研究[J].眼科新进展,2016,36(1):26-30.
[14]刘青兰,刘琳,李留炀,等.曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓的疗效及安全性观察[J].实用口腔医学杂志,2017,33(4):536-540.
[15]Gaines TL,Beletsky L,Arredondo J,et al.Examining the spatial distribution of law enforcement encounters among people who inject drugs after implementation of Mexico's drug policy reform[J].J Urban Health,2015,92(2):338-351.
[16]李勉香,吴桐,杨灵澜,等.曲安奈德口腔软膏治疗糜烂型口腔扁平苔藓临床疗效观察[J].实用口腔医学杂志,2016,32(4):581-583.
[17]Pakulska MM,Vulic K,Tam RY,et al.Hybrid crosslinked methylcellulose hydrogel:a predictable and tunable platform for local drug delivery[J].Adv Mater,2015,27(34):5002-5008
[18]巨立中,方秀凤,刘国才,等.曲安奈德联合玻璃酸钠关节腔注射治疗炎性关节病[J].实用医学杂志,2016,32(1):156-157.
[2]中华医学会眼科学分会神经眼科学组.我国非动脉炎性前部缺血性视神经病变诊断和治疗专家共识(2015年)[J].中华眼科杂志,2015,51(5):323-326.
[3]李明,刘少倩,陈碾,等.自体组织再造睑板联合颞区皮瓣修复下眼睑全层缺损[J].中南大学学报(医学版),2017,42(6):662-666.
[4]李洪霞,韩冰,于艳,等.儿童Majocchi肉芽肿1例[J].中国皮肤性病学杂志,2017,31(6):658-659.
[5]Forcucci J,Butlerwilliams S,Miller N,et al.Plasma cell granuloma:An entity within the spectrum of IgG4-related disease[J].Ann Clin Lab Sci,2015,45(3):340-343.
[6]赵佐芳,王宁,王大庆,等.眼睑基底细胞癌相关成纤维细胞与正常成纤维细胞形态与生长增殖特性差异[J].眼科新进展,2016,36(4):327-330.
[7]Likhitpanichkul M,Kim Y,Torre OM,et al.Fibrin-genipin annulus fibrosus sealant as a delivery system for anti-TNFαdrug[J].Spine J,2015,15(9):2045-2054.
[8]Hayle S.Comparing drug policy windows internationally:drug consumption room policy making in canada and england and wales[J].Contemporary Drug Problems,2015,42(1):20-37.
[9]丁雪,孙玉明,孙盟,等.曲安奈德在聚丙烯酸酯压敏胶中稳定性研究[J].大连理工大学学报,2017,57(5):441-446.
[10]向臻婷,郑晓辉.药物局部注射治疗原发性三叉神经痛的研究进展[J].国际口腔医学杂志,2016,43(1):38-42.
[11]庆惠玲,李晓华,张俊鸽,等.眼睑近泪小点肿物切除56例疗效分析[J].眼科新进展,2015,35(2):141-143.
[12]Petousis-Harris H,Jackson C,Stewart J,et al.Factors associated with reported pain on injection and reactogenicity to an OMV meningococcal B vaccine in children and adolescents[J].Human Vaccines,2015,11(7):1872-1877.
[13]吴晓蓉,邹晶,邵毅,等.睑板下注射曲安奈德改善活动期春季角结膜炎患者眼表症状的临床研究[J].眼科新进展,2016,36(1):26-30.
[14]刘青兰,刘琳,李留炀,等.曲安奈德口腔软膏治疗充血糜烂型口腔扁平苔藓的疗效及安全性观察[J].实用口腔医学杂志,2017,33(4):536-540.
[15]Gaines TL,Beletsky L,Arredondo J,et al.Examining the spatial distribution of law enforcement encounters among people who inject drugs after implementation of Mexico's drug policy reform[J].J Urban Health,2015,92(2):338-351.
[16]李勉香,吴桐,杨灵澜,等.曲安奈德口腔软膏治疗糜烂型口腔扁平苔藓临床疗效观察[J].实用口腔医学杂志,2016,32(4):581-583.
[17]Pakulska MM,Vulic K,Tam RY,et al.Hybrid crosslinked methylcellulose hydrogel:a predictable and tunable platform for local drug delivery[J].Adv Mater,2015,27(34):5002-5008
[18]巨立中,方秀凤,刘国才,等.曲安奈德联合玻璃酸钠关节腔注射治疗炎性关节病[J].实用医学杂志,2016,32(1):156-157.