急性脑梗死患者BNP、Hcy、D-D、FIB水平变化的临床研究
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摘要
目的探讨脑钠肽(BNP)、同型半胱氨酸(Hcy)、D-二聚体(D-D)、纤维蛋白原(FIB)水平检测在急性脑梗死(ACI)中的应用价值。方法 136例急性脑梗死患者作为实验组, 110例健康体检者作为对照组,比较两组血清BNP、Hcy和血浆D-D、FIB水平。结果实验组患者血清BNP、Hcy和血浆D-D、FIB水平分别为(219.3±20.9)pg/ml、(29.21±3.14)μmol/L、(1.97±0.62)mg/L、(6.01±1.72)g/L,均高于对照组的(46.7±11.5)pg/ml、(10.45±1.71)μmol/L、(0.29±0.89)mg/L、(2.41±1.09)g/L,差异具有统计学意义(P<0.05)。结论联合检测血清BNP、Hcy和血浆D-D、FIB水平对于急性脑梗死患者的早期诊断、指导治疗及判断病情严重程度具有重要意义。
Objective To discuss the application value of B-type natriuretic peptide(BNP), homocysteine(Hcy), D-dimer(D-D) and fibrinogen(FIB) level detection in acute cerebral infarction(ACI). Methods There were 136 acute cerebral infarction patients as experimental group, and 110 health examination persons as control group. The serum BNP and Hcy, and plasma D-D and FIB level in two groups was compared. Results The experimental group had higher serum BNP and Hcy, and plasma D-D and FIB level respectively as(219.3±20.9) pg/ml,(29.21±3.14) μmol/L,(1.97±0.62) mg/L and(6.01±1.72) g/L than(46.7±11.5) pg/ml,(10.45±1.71) μmol/L,(0.29±0.89) mg/L and(2.41±1.09) g/L in the control group, and their difference was statistically significant(P<0.05). Conclusion Combined detection of serum BNP and Hcy, and plasma D-D and FIB level shows important significance in early diagnosis, guidance and judge the severity of disease in patients with acute cerebral infarction.
Objective To discuss the application value of B-type natriuretic peptide(BNP), homocysteine(Hcy), D-dimer(D-D) and fibrinogen(FIB) level detection in acute cerebral infarction(ACI). Methods There were 136 acute cerebral infarction patients as experimental group, and 110 health examination persons as control group. The serum BNP and Hcy, and plasma D-D and FIB level in two groups was compared. Results The experimental group had higher serum BNP and Hcy, and plasma D-D and FIB level respectively as(219.3±20.9) pg/ml,(29.21±3.14) μmol/L,(1.97±0.62) mg/L and(6.01±1.72) g/L than(46.7±11.5) pg/ml,(10.45±1.71) μmol/L,(0.29±0.89) mg/L and(2.41±1.09) g/L in the control group, and their difference was statistically significant(P<0.05). Conclusion Combined detection of serum BNP and Hcy, and plasma D-D and FIB level shows important significance in early diagnosis, guidance and judge the severity of disease in patients with acute cerebral infarction.
引文
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[5]郑金书,刘爽,王青银,等.血浆同型半胱氨酸水平与颈动脉粥样硬化及脑梗死的相关性.安徽医学, 2010, 31(9):1072-1074.
[6]彭乃杰,李克诚,夏菲,等.血清同型半胱氨酸水平与急性脑梗死的相关性研究.检验医学, 2013, 28(3):257-258.
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[8]刘进香,吴兴军,徐艳红,等.急性脑梗死TOAST分型与血浆纤维蛋白原的相关研究.脑与神经疾病杂志, 2013, 21(1):79-80.
[9]张庆侠,王田园,张然蓉,等.血生化标志物联合检测对急性缺血性脑卒中的诊断价值.中国热带医学, 2012, 12(5):593-595.
[2]陈欣,关兰芳,马赟英,等.进展性缺血性脑卒中危险因素及其预测价值研究.卒中与神经疾病, 2016, 23(6):392-395.
[3]梁顺容,王希平,黄子安.中老年急性脑梗死患者3项生化指标水平变化的临床意义.国际检验医学杂志, 2013, 11(2):1454.
[4]汪进丁,万和斌,万姗姗,等.老年急性缺血性脑梗死患者血清N端脑钠肽前体水平的变化及意义.中国当代医药, 2013,31(3):46.
[5]郑金书,刘爽,王青银,等.血浆同型半胱氨酸水平与颈动脉粥样硬化及脑梗死的相关性.安徽医学, 2010, 31(9):1072-1074.
[6]彭乃杰,李克诚,夏菲,等.血清同型半胱氨酸水平与急性脑梗死的相关性研究.检验医学, 2013, 28(3):257-258.
[7]府伟灵,徐克前.临床生物化学检验.第5版.北京:人民卫生出版社, 2013:216-217.
[8]刘进香,吴兴军,徐艳红,等.急性脑梗死TOAST分型与血浆纤维蛋白原的相关研究.脑与神经疾病杂志, 2013, 21(1):79-80.
[9]张庆侠,王田园,张然蓉,等.血生化标志物联合检测对急性缺血性脑卒中的诊断价值.中国热带医学, 2012, 12(5):593-595.