柴胡和黄芩配伍的研究进展
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摘要
配伍是中药复方用药的特色和优势,而药对则是最常见的配伍形式。柴胡、黄芩配伍出自《伤寒论》的小柴胡汤方,是张仲景柴胡系列方剂中最具代表意义的基本配伍,也是和解少阳的基本结构。柴胡和黄芩配伍的临床应用十分广泛,如治疗心血管系统疾病、消化系统疾病、呼吸系统疾病、精神神志系统疾病以及发热等都有显著疗效。研究显示,柴胡、黄芩配伍具有保肝利胆、抗病毒、解热抗炎、抗惊厥抗癫痫等药理作用,故从临床研究和实验研究两方面对柴胡、黄芩配伍进行综述,根据黄芩的主要药效成分黄酮类及柴胡和柴胡的主要成分柴胡皂苷均具有抗抑郁作用,且配伍后黄芩苷和柴胡皂苷溶出率均提高,以及临床治疗抑郁症常用的柴胡类方(柴胡为君药)多常配伍黄芩清热泻火等推断,即柴胡配伍黄芩可能具有一定程度的抗抑郁作用,但仍需学者进一步证实。
Compatibility is the characteristics and advantages of traditional Chinese medicine compound medication,and the drug pair is the most common form of compatibility. The compatibility of Radix Bupleuri and Radix Scutellariae is from the small bupleurum soup of "Treatise on Febrile Diseases",which is the most representative basic compatibility of Zhongjing's series of radix bupleuri prescription,and is also the basic structure of reconciliating Shaoyang. Clinical application of the Compatibility of Radix Bupleuri and Radix Scutellariae is very extensive,such as treat cardiovascular disease,digestive diseases,respiratory diseases,psychiatric system diseases and fever and so on. And it has achieved significant effect. Studies have shown that the Compatibility of Radix Bupleuri and Radix Scutellariae has a pharmacological effect of liver and gallbladder,anti-virus,antipyretic anti-inflammatory,anti-convulsive antiepileptic and so on. In this paper,the compatibility of Radix Bupleuri and Radix Scutellariae was summarized from two aspects of Clinical research and experimental research. According to the main pharmacological constituents of Scutellaria, flavonoids and the main components of Bupleurum and Radix Bupleuri were all antidepressant. And after compatibility,the dissolution rate of baicalin and saikosaponin were increased. As well as the clinical treatment of depression commonly used Bupleurum square( Bupleurum for Jun medicine) often compatibility Huang Qin to clearing heat and purging fire. Taking these all into account,we infer that: compatibility of radix bupleuri and radix scutellariae may have a certain degree of antidepressant effect. But it still needs scholars to further confirm.
Compatibility is the characteristics and advantages of traditional Chinese medicine compound medication,and the drug pair is the most common form of compatibility. The compatibility of Radix Bupleuri and Radix Scutellariae is from the small bupleurum soup of "Treatise on Febrile Diseases",which is the most representative basic compatibility of Zhongjing's series of radix bupleuri prescription,and is also the basic structure of reconciliating Shaoyang. Clinical application of the Compatibility of Radix Bupleuri and Radix Scutellariae is very extensive,such as treat cardiovascular disease,digestive diseases,respiratory diseases,psychiatric system diseases and fever and so on. And it has achieved significant effect. Studies have shown that the Compatibility of Radix Bupleuri and Radix Scutellariae has a pharmacological effect of liver and gallbladder,anti-virus,antipyretic anti-inflammatory,anti-convulsive antiepileptic and so on. In this paper,the compatibility of Radix Bupleuri and Radix Scutellariae was summarized from two aspects of Clinical research and experimental research. According to the main pharmacological constituents of Scutellaria, flavonoids and the main components of Bupleurum and Radix Bupleuri were all antidepressant. And after compatibility,the dissolution rate of baicalin and saikosaponin were increased. As well as the clinical treatment of depression commonly used Bupleurum square( Bupleurum for Jun medicine) often compatibility Huang Qin to clearing heat and purging fire. Taking these all into account,we infer that: compatibility of radix bupleuri and radix scutellariae may have a certain degree of antidepressant effect. But it still needs scholars to further confirm.
引文
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[4]王纶.明医杂著[M].长春:时代文艺出版社,2008:2.
[5]王文姣.浅析小柴胡汤在心血管疾病治疗中的作用[J].中西医结合心血管病杂志,2016,4(25):159-160.
[6]唐剑兰.藿香正气散合小柴胡汤加减治疗胃肠型感冒[J].实用中西医结合临床,2014,14(3):42-43.
[7]王芬芬.小柴胡汤治疗消化系统疾病概述[J].实用中医药杂志,2016,32(10):1038-1039.
[8]李时珍.本草纲目(上册)[M].北京:人民卫生出版社,1985:785-788.
[9]黄元御.长沙药解[M].张蕾,翟燕,孙清伟,校注.北京:中国中医药出版社,2016:75.
[10]刘朝霞,李国庆,李贺薇.谢晶日教授运用柴胡系药对治疗消化内科疾病经验阐析[J].内蒙古中医药,2016,17:68.
[11]李宏艳.小柴胡汤在肺系疾病中的应用[J].中西医结合心血管病杂志,2015,3(8):197-198.
[12]陈华,李岚.俞景茂和解少阳法治疗小儿呼吸系统疾病的经验[J].浙江中医杂志,2012,45(12):868-869.
[13]丁德正.小柴胡汤在精神疾病中的运用[J].中华中医药杂志,2011,26(8):1765-1767.
[14]黄波.黄煌运用柴胡加龙骨牡蛎汤经验举隅[J].江苏中医药,2008,40(3):32-33.
[15]倪朱谟.本草汇言[M].戴慎,陈仁寿,虞舜,点校.上海:上海科学技术出版社,2005:49.
[16]孙一奎.赤水玄珠[M].周琦,校注.北京:中国医药科技出版社,2011:704.
[17]谭畅,韦志辉.小柴胡汤治疗外感发热35例[J].辽宁中医学院学报,2004,6(3):192.
[18]刘辉英,楼轩华.小柴胡汤治疗产后高热86例[J].中医中药,2002,73(4):86.
[19]张树彪.小柴胡汤加减治疗传染性单核细胞增多症高热21例[J].新中医,2003,35(5):57.
[20]李璐,张影,王宪龄.柴胡、黄芩及小柴胡汤抗肿瘤研究[J].中医研究,2013,8:79-80.
[21]程保智.柴胡桂枝干姜汤治疗糖尿病体会[J].中国中医药信息杂志,2011,18(5):81-83.
[22]王宪龄,李伟,刘方洲,等.柴胡黄芩配伍对CCl4所致小鼠急性肝损伤的研究[J].中药药理与临床,2005,21(6):11-13.
[23]王宪龄,程玲,宋宁,等.柴胡黄芩及两者不同比例配伍抗大鼠CCl4慢性肝损伤作用的比较研究[J].中药药理与临床,2009,25(6):70-73.
[24]李敏,王斌,候建平,等.柴胡、黄芩及其配伍抗大鼠肝纤维化作用研究[J].天津中医药,2012,29(6):576-578.
[25]王宪龄,李连珍,牛万强.柴胡与黄芩不同剂量比例配伍对扑热息痛所致小鼠急性肝损伤的保护作用[J].河南中医,2004,24(8):15-17.
[26]刘仁慧,王宪龄,宋宁.柴胡黄芩配伍解酒作用研究[J].中药药理与临床,2004,20(4):3-4.
[27]谢炜.柴胡黄芩配伍抗大鼠急性酒精性肝损伤作用研究[J].中药研究,2013,15(2):210-214.
[28]王宪龄,刘仁慧,刘方洲,等.柴胡黄芩配伍对大鼠急性酒精性肝损伤整体调节作用初探[J].中医研究,2004,17(5):24-25.
[29]王宪龄,刘仁慧,张影,等.柴胡黄芩配伍抗小鼠急性酒精性肝损伤的实验研究[J].中药材,2004,27(10):756-758.
[30]刘芳,王雪峰,闫丽娟,等.黄芩、柴胡及其配伍提取物对心肌炎小鼠心肌组织CVB3m RNA及IFNm RNA表达的影响[J].中华中医药学刊,2010,28(8):1601-1604.
[31]刘芳,王雪峰,南春红,等.黄芩、柴胡及其配伍提取物对柯萨奇病毒B3m感染Balb/c小鼠心肌炎治疗作用[J].中华中医药杂志,2011,26(4):697-700.
[32]刘芳,王雪峰,南春红,等.黄芩、柴胡对CVB3m小鼠心肌炎凋亡及相关基因Bcl-2/Bax表达的影响[J].中药药理与临床,2010,26(6):53-56.
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