注射用丹参多酚酸药理作用及临床应用研究进展
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摘要
注射用丹参多酚酸是以唇形科丹参药材为原料,采用现代先进工艺提取、分离其水溶性酚酸类有效成分研制而成的新一代中药注射剂。药理研究表明,丹参多酚酸对缺血性脑损伤具有抗炎、抗氧化应激、神经营养、再生和保护的作用,同时能够减轻心肌缺血损伤和糖尿病肾损伤。在临床上主要用于中风病(轻中度脑梗死)恢复期瘀血阻络证的治疗,近年来也逐步拓展应用到了急性脑梗死、呼吸综合征等方面的治疗。主要对注射用丹参多酚酸上市以来的药理作用、临床应用及安全性评价加以综述,为进一步开展基础试验提供研究线索,为临床推广应用提供参考依据。
Salvianolic Acids for Injection(SAFI) using Salvia miltiorrhiza as raw material is a new generation of traditional Chinese medicine injection which is made by modern advanced technology to extract and separate the effective components of water-soluble phenolic acids. Modern pharmacological research shows that SAFI has the pharmacological effects of anti-inflammatory, antioxidative stress, neurotrophic, regeneration and protective effects on ischemic brain injury. At the same time, it can reduce myocardial ischemia and diabetic kidney injury. It is mainly used for the treatment of stroke(mild to moderate cerebral infarction).In recent years, it has also been gradually extended to the treatment of acute cerebral infarction and respiratory syndrome.Pharmacological action, clinical application, and safety evaluation of SAFI were reviewed in this article, to provide a clue for the further development of the basic research and a reference for the clinical application.
Salvianolic Acids for Injection(SAFI) using Salvia miltiorrhiza as raw material is a new generation of traditional Chinese medicine injection which is made by modern advanced technology to extract and separate the effective components of water-soluble phenolic acids. Modern pharmacological research shows that SAFI has the pharmacological effects of anti-inflammatory, antioxidative stress, neurotrophic, regeneration and protective effects on ischemic brain injury. At the same time, it can reduce myocardial ischemia and diabetic kidney injury. It is mainly used for the treatment of stroke(mild to moderate cerebral infarction).In recent years, it has also been gradually extended to the treatment of acute cerebral infarction and respiratory syndrome.Pharmacological action, clinical application, and safety evaluation of SAFI were reviewed in this article, to provide a clue for the further development of the basic research and a reference for the clinical application.
引文
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[6]李富强,王伟,尹金鹏,等.大鼠脑缺血再灌注后线粒体ATP酶活性、形态学变化及丹参多酚酸的保护作用[J].中风与神经疾病杂志, 2018(3):238-241.
[7] Tang H, Pan C S, Mao X W, et al. Role of NADPH oxidase in total salvianolicacid injection attenuating ischemia-reperfusion impaired cerebral microcirculation and neurons:Implication of AMPK/Akt/PKC[J].Microcirculation, 2014, 21(7):615.
[8] Hou S, Zhao M M, et al. Neuro-protective Effect of salvianolic acids against cerebral ischemia reperfusion injury[J]. Int J Mol Sci, 2016, 17:1190.
[9]袁庆,胡利民,王少峡,等.注射用丹参多酚酸对胶质细胞神经营养因子及神经元的保护作用[J].中国临床药理学杂志, 2017, 33(10):893-896.
[10]王富江,李芮琳,贾壮壮,等.注射用丹参多酚酸和血栓通注射液联合应用对局灶性脑缺血再灌注大鼠脑组织星形胶质细胞和小胶质细胞的影响及作用机制研究[J].中草药, 2017, 48(19):4029-4036.
[11]何前松,况时祥,王少峡,等.丹参多酚酸对脑缺血再灌注损伤糖尿病大鼠神经功能及微管相关蛋白2表达的影响[J].中华行为医学与脑科学杂志, 2015, 24(10):877-881.
[12]何前松,马萌萌,胡利民,等.丹参多酚酸对大鼠糖尿病脑缺血再灌注损伤恢复期相关基因表达的影响[J].中国实验方剂学杂志, 2015, 21(7):80-86.
[13]王富江,何前松,王金鑫,等.注射用丹参多酚酸治疗糖尿病大鼠脑卒中的基因芯片表达谱分析[J].中国药理学通报, 2017, 33(8):1103-1109.
[14] He Q, Wang S, Liu X, et al. Salvianolate lyophilized injection promotes post-stroke functional recovery via the activation of VEGF and BDNF-Trk B-CREB signaling pathway[J]. Int J Clin Exp Med, 2015, 8(1):108.
[15] Zhang Y, Zhang X, Cui L, et al. Salvianolic Acids for Injection(SAFI)promotes functional recovery and neurogenesis via sonic hedgehog pathway after stroke in mice[J]. Neurochem Int, 2017, 110:38-48.
[16] Yin X, Feng Lsh, Ma D, et al. Roles of astrocytic connexin-43, hemichannels, and gap junctions inoxygenglucosedeprivation/reperfusioninjury induced neuroinflammation and thepossible regulatory mechanisms ofsalvianolic acid B and carbenoxolone[J]. J Neuroinflamm, 2018, 15:97.
[17] Shen L, Han B, Geng Y, et al. Amelioration of cognitiveimpairments in APPswe/PS1d E9 mice isassociated with metabolites alteration induced bytotal salvianolic acid[J]. PLo S ONE, 2017, 12(3):e0174763.
[18] Guo G Q, Li B, Wang Y Y, et al. Effects of salvianolic acid B on proliferation, neurite outgrowth and differentiation of neural stem cells derived from the cerebral cortex of embryonic mice[J]. Sci Chin Life Sci,2010, 53(6):653-662.
[19] Zhuang P, Zhang Y, Cui G, et al. Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B[J]. PLo S One,2012, 7(4):e35636.
[20]鞠爱春,耿诗涵,杨欣鹏,等.丹酚酸B鼻腔给药对脑缺血损伤大鼠学习记忆能力及神经再生的影响[J].中草药, 2017, 48(12):2481-2485.
[21]王靖,甄江涛,田志辉,等.丹参多酚酸对大鼠缺血心肌线粒体酶的影响[J].天津医科大学学报, 2012, 18(3):295-298.
[22] Tang M K, Ren D C, Zhang J T, et al. Effect of salvianolic acids from Radix Salviae miltiorrhizaeon regional cerebral blood flow and platelet aggregationin rats[J]. Phytomedicine, 2002, 9:405-409.
[23] Li G, Zhang Y L, Li Z Y, et al. Salvianolic acids attenuate rat hippocampal injury after acute CO poisoning by improving blood flow properties[J]. Bio Med Res Int,2015. DOI:10.1155/2015/526483.
[24] Wang M X, Liu Y Y, Hu B H, et al. Total salvianolic acid improves ischemia-reperfusion-induced microcirculatory disturbance in rat mesentery[J]. World J Gastroenterol,2010, 16(42):5306-5316.
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