玉芪扶正汤治疗糖尿病肾病临床研究
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摘要
目的:观察玉芪扶正汤治疗糖尿病肾病的临床效果。方法:选择糖尿病肾病患者100例,采用随机数字表法分为对照组和观察组各50例,对照组采用常规治疗,观察组在对照组基础上联合玉芪扶正汤口服。比较2组临床效果,检测2组治疗前后血肌酐(SC)r、血尿素氮(BUN)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、尿蛋白排泄率(UAER)、尿微球蛋白(μβ-MG)、24小时尿蛋白定量的变化情况。结果:治疗前,2组SCr、BUN、TG、TC水平比较,差异无统计学意义(P>0.05)。治疗后,2组SCr、BUN、TG、TC水平较治疗前降低,且观察组SCr、BUN、TG、TC水平均低于对照组,差异均有统计学意义(P <0.05)。治疗前,2组LDL、UAER、μβ-MG、24小时尿蛋白定量各项指标比较,差异无统计学意义(P> 0.05)。治疗后,2组LDL、UAER、μβ-MG、24小时尿蛋白定量较治疗前均显著降低,且观察组上述指标均低于对照组,差异均有统计学意义(P <0.05)。观察组总有效率为92.0%,显著高于对照组的76.0%,差异有统计学意义(P <0.05)。结论:玉芪扶正汤治疗糖尿病肾病有确切疗效,值得临床应用与推广。
Objective:To observe the clinical effect of Yuqi Fuzheng tang for diabetic nephropathy. Methods:Selected 100 cases of patients with diabetic nephropathy,and divided them into the control group and the observation group randomly,50 cases in each group. The control group received routine treatment,while the observation group additionally received the oral administration of Yuqi Fuzheng tang. Compared the clinical effect in both groups,and detected the changes in levels of serum creatinine(SCr), blood urea nitrogen(BUN), triglyceride(TG), total cholesterol(TC), low-density lipoprotein(LDL), urinary albumin excretion rate(UAER),urine microglobulin(μβ-MG) and 24-hour urinary protein quantity. Results:Before treatment,comparing the levels of SCr,BUN,TG and TC in both groups,there was no significant difference being found(P > 0.05).After treatment,the levels of SCr,BUN,TG and TC in both groups were lower than those before treatment,and each index in the observation group was lower than that in the control group,differences being significant(P < 0.05). Before treatment,comparing the levels of LDL and μβ-MG,UAER and 24-hour urinary protein quantity in both groups,there was no significant difference being found(P > 0.05). After treatment,the levels of LDL and μβ-MG,UAER and 24-hour urinary protein quantity in both groups were evidently lower than those before treatment, and each index in the observation group was evidently lower than that in the control group,differences being significant(P < 0.05). The total effective rate was 92.0% in the observation group, being evidently higher than 76.0% in the control group, difference being significant(P < 0.05). Conclusion: Yuqi Fuzheng tang has exact therapeutic effect in treating diabetic nephropathy, which is worthy of clinical application and promotion.
Objective:To observe the clinical effect of Yuqi Fuzheng tang for diabetic nephropathy. Methods:Selected 100 cases of patients with diabetic nephropathy,and divided them into the control group and the observation group randomly,50 cases in each group. The control group received routine treatment,while the observation group additionally received the oral administration of Yuqi Fuzheng tang. Compared the clinical effect in both groups,and detected the changes in levels of serum creatinine(SCr), blood urea nitrogen(BUN), triglyceride(TG), total cholesterol(TC), low-density lipoprotein(LDL), urinary albumin excretion rate(UAER),urine microglobulin(μβ-MG) and 24-hour urinary protein quantity. Results:Before treatment,comparing the levels of SCr,BUN,TG and TC in both groups,there was no significant difference being found(P > 0.05).After treatment,the levels of SCr,BUN,TG and TC in both groups were lower than those before treatment,and each index in the observation group was lower than that in the control group,differences being significant(P < 0.05). Before treatment,comparing the levels of LDL and μβ-MG,UAER and 24-hour urinary protein quantity in both groups,there was no significant difference being found(P > 0.05). After treatment,the levels of LDL and μβ-MG,UAER and 24-hour urinary protein quantity in both groups were evidently lower than those before treatment, and each index in the observation group was evidently lower than that in the control group,differences being significant(P < 0.05). The total effective rate was 92.0% in the observation group, being evidently higher than 76.0% in the control group, difference being significant(P < 0.05). Conclusion: Yuqi Fuzheng tang has exact therapeutic effect in treating diabetic nephropathy, which is worthy of clinical application and promotion.
引文
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[8]李幼阳,孙晓,单建宁,等.单煎黄芪配合一般西药对糖尿病肾病患者尿液微量白蛋白等4项指标的影响[J].沈阳部队医药,2001,14(4):347-348.
[9]丁夏楠,许筠,苏建平,等.益肾逐瘀方治疗糖尿病肾病蛋白尿37例[J].西部中医药,2014,27(4):96-97.
[10]俞俊萍,王吉如,方明,等.黄芪注射液联用葛根素注射液对2型糖尿病肾病微量蛋白尿的影响[J].医药导报,2005,24(1):38-39.
[2]朱万玲,钱秋海.中西医对糖尿病合并痛风的病因病机研究[J].辽宁中医药大学学报,2014,16(5):137-139.
[3]郑筱萸.中药新药临床研究指导原则(试行)[M].北京:中国医药科技出版社,2002.
[4]牛春波,李建华.糖尿病肾病发病机制及治疗研究新进展[J].国际检验医学杂志,2014,35(16):2204-2206.
[5]迪丽努·吐尔洪.糖尿病肾病的中医治疗特色[C]//中国中西医结合学会.中国中西医结合学会肾脏疾病专业委员会2012年学术年会论文集.2012:597-598.
[6]杨勤军,张星星,李泽庚,等.论唐宗海《血证论》辨治内伤咳嗽思想[J].中华中医药杂志,2018,33(9):3799-3801.
[7]谷华,丁孝良,孙宝军.HPLC法测定玉屏风颗粒中黄芪甲苷及甘露醇的含量[J].世界中医药,2019,14(4):839-843.
[8]李幼阳,孙晓,单建宁,等.单煎黄芪配合一般西药对糖尿病肾病患者尿液微量白蛋白等4项指标的影响[J].沈阳部队医药,2001,14(4):347-348.
[9]丁夏楠,许筠,苏建平,等.益肾逐瘀方治疗糖尿病肾病蛋白尿37例[J].西部中医药,2014,27(4):96-97.
[10]俞俊萍,王吉如,方明,等.黄芪注射液联用葛根素注射液对2型糖尿病肾病微量蛋白尿的影响[J].医药导报,2005,24(1):38-39.