梅国强自拟方四土汤探析
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摘要
"四土汤"系国医大师梅国强教授的自拟方之一,由土茯苓,土大黄,土牛膝,土贝母组成。本文对方中各药性味、归经、功效、临床应用逐一进行分析,结合梅老运用四土汤的临床经验和方中各药的药理作用,推测全方药理作用及其作用机制,为临床应用本方提供理论和实验依据。
Situ decoction is the one of self-made prescriptions by Chinese medicine master Mei Guoqiang, The taste,meridian,efficacy and clinical application of each herb were analyzed,combined with master Mei's clinical experience on this decoction with the pharmacological effects,we speculated the pharmacological effect and mechanism,aiming to provide theoretical and experimental basis for the clinical application of the decoction.
Situ decoction is the one of self-made prescriptions by Chinese medicine master Mei Guoqiang, The taste,meridian,efficacy and clinical application of each herb were analyzed,combined with master Mei's clinical experience on this decoction with the pharmacological effects,we speculated the pharmacological effect and mechanism,aiming to provide theoretical and experimental basis for the clinical application of the decoction.
引文
[1]高学敏.中药学[M].北京:中国中医药出版社,2002:79.
[2]李强.土茯苓现代研究概述[J].中国药业,2008,17(14):76-78.
[3]熊常初,龙利.土茯苓现代药理作用浅谈[J].国医论坛,2012,27(5):38-39.
[4]热比姑丽·伊斯拉木,斯拉甫·艾白.土大黄研究进展[J].科技导报,2013,31(30):67-71.
[5]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006:85.
[6]潘东来,顾敬文,银胜高,等.土牛膝文献统计分析与研究进展[J].亚太传统医药,2017,13(13):44-47.
[7]林伟波,林长峰,梅国强.梅国强运用四土汤治疗顽疾验案分析[J].上海中医药杂志,2012,46(9):16-17.
[8]黄慧莲,刘科兰,刘荣华,等.国内外菝葜科植物药效研究进展[J].中华中医药杂志,2012,27(11):2899-2902.
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[10]欧丽兰,余昕,朱烨,等.土牛膝在急性炎症动物模型中的抗炎作用[J].华西药学杂志,2012,27(6):644-646.
[11]石会丽,韩燕萍,肖会玲.土贝母的药理作用研究进展[J].陕西中医,2004,25(9):857-858.
[12]殷网虎,袁武军,曹美琳.土茯苓配方颗粒对临床常见致病菌的抗菌研究[J].中国中医急症,2011,20(12):1957-1958.
[13]刘红淼,李艳玲,杨继章.土大黄的药理作用及临床应用研究进展[J].中国药房,2013,24(15):1422-1425.
[14]郭静科,张雯,陈娟,等.闽产土牛膝抑菌活性的研究[J].福州大学学报,2005,33(2):269-272.
[15]Sa F,Gao JL,Fung KP.Anti-proliferative and proapoptotic effect of Roxb.extract on hepatoma celllines[J].Chemico-Biological Interactions,2008(171):1-14.
[16]王建平,张海燕,傅旭春.土茯苓的化学成分和药理作用研究进展[J].海峡药学,2013,25(1):42-44.
[17]张广庆,赵海鹏,王振月,等.酸模属植物的化学成分与药理活性研究进展[J].世界科学技术-中医药现代化,2008,10(5):86-93.
[18]孙健,温庆辉.土贝母的化学成分及药理作用研究进展[J].中国药物警戒,2010,7(7):430-431.
[19]周艳萌,吴中明,向晓波.土贝母皂苷体外抗乙型肝炎病毒的药效研究[J].时珍国医国药,2006,17(11):2134-2136.
[20]秦汝兰,黄田玉,高璐.土茯苓中总黄酮提取方法及药理作用[J].通化师范学院学报,2010,31(2):39-41.
[21]李伟平,何良艳,马哲龙,等.土牛膝多糖抗炎镇痛作用的研究[J].中华中医药学刊,2012,30(4):747-749.
[22]Maksimovic Z,Kovacevic N,Lakusic B,et al.Antioxidant activity of yellow dock(L.,Polygonaceae)fruit extract[J].Phytotherapy Research,2011,25(1):101-105.
[23]孙晓龙,王宽宇,张丹琦.土茯苓注射液对大鼠血栓形成影响的实验研究[J].中国中医药科技,2004,11(4):229-231.
[24]Irshad AL,Gurpreet K,Mohammad A,et al.Protective effect of(English Spinach)roots on ferric nitrilotriacetate(Fe-NTA)induced hepatic oxidative stress and tumor promotion response[J].Food Chem Toxicol,2007,45(10):1821-1829.
[25]张燕,李治建,夏木西努尔·肖盖提,等.土大黄化学成分及药理作用研究进展[J].中药药理与临床,2012,28(3):173-176.
[26]袁精玉.土牛膝新鲜品和陈品抗脂质过氧化作用药效比较[J].江西中医学院学报,2007,19(2):79.
[27]陈红明.通痹土茯苓汤治疗急性痛风性关节炎80例观察[J].实用医药杂志,2010,26(8):528-529.
[28]Xia DZ,Yu XF,Liao SP.Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats[J].Journal of Ethnopharmacology,2010(130):414-420.
[29]黄青,瞿幸,吴清.黄连、土大黄、苍术提取液抗银屑病实验研究[J].中国中医药信息杂志,2008,15(6):30-31.
[30]方芳,王立国,李妍,等.羊蹄根对原发性血小板减少性紫癜模型小鼠外周血小板的影响[J].时珍国医国药,2012,23(4):919-920.
[31]马健康,方芳,李艳.羊蹄根对免疫性血小板减少性紫癜小鼠模型的治疗作用[J].中国免疫学杂志,2011,27(4):363-364.
[32]马文杰,魏得良,黄志芳,等.土牛膝提取物对正常及四氧嘧啶糖尿病模型小鼠血糖的影响[J].当代医学,2010,16(30):4-5.
[2]李强.土茯苓现代研究概述[J].中国药业,2008,17(14):76-78.
[3]熊常初,龙利.土茯苓现代药理作用浅谈[J].国医论坛,2012,27(5):38-39.
[4]热比姑丽·伊斯拉木,斯拉甫·艾白.土大黄研究进展[J].科技导报,2013,31(30):67-71.
[5]南京中医药大学.中药大辞典[M].上海:上海科学技术出版社,2006:85.
[6]潘东来,顾敬文,银胜高,等.土牛膝文献统计分析与研究进展[J].亚太传统医药,2017,13(13):44-47.
[7]林伟波,林长峰,梅国强.梅国强运用四土汤治疗顽疾验案分析[J].上海中医药杂志,2012,46(9):16-17.
[8]黄慧莲,刘科兰,刘荣华,等.国内外菝葜科植物药效研究进展[J].中华中医药杂志,2012,27(11):2899-2902.
[9]Lee HS,Kim SK,Han JB,et al.Inhibitory effects of Rumex japonicus Houtt.on the development of atopic dermatitis-like skin lesions in NC/Nga mice[J].Br J Dermatol,2006,155(1):33-38.
[10]欧丽兰,余昕,朱烨,等.土牛膝在急性炎症动物模型中的抗炎作用[J].华西药学杂志,2012,27(6):644-646.
[11]石会丽,韩燕萍,肖会玲.土贝母的药理作用研究进展[J].陕西中医,2004,25(9):857-858.
[12]殷网虎,袁武军,曹美琳.土茯苓配方颗粒对临床常见致病菌的抗菌研究[J].中国中医急症,2011,20(12):1957-1958.
[13]刘红淼,李艳玲,杨继章.土大黄的药理作用及临床应用研究进展[J].中国药房,2013,24(15):1422-1425.
[14]郭静科,张雯,陈娟,等.闽产土牛膝抑菌活性的研究[J].福州大学学报,2005,33(2):269-272.
[15]Sa F,Gao JL,Fung KP.Anti-proliferative and proapoptotic effect of Roxb.extract on hepatoma celllines[J].Chemico-Biological Interactions,2008(171):1-14.
[16]王建平,张海燕,傅旭春.土茯苓的化学成分和药理作用研究进展[J].海峡药学,2013,25(1):42-44.
[17]张广庆,赵海鹏,王振月,等.酸模属植物的化学成分与药理活性研究进展[J].世界科学技术-中医药现代化,2008,10(5):86-93.
[18]孙健,温庆辉.土贝母的化学成分及药理作用研究进展[J].中国药物警戒,2010,7(7):430-431.
[19]周艳萌,吴中明,向晓波.土贝母皂苷体外抗乙型肝炎病毒的药效研究[J].时珍国医国药,2006,17(11):2134-2136.
[20]秦汝兰,黄田玉,高璐.土茯苓中总黄酮提取方法及药理作用[J].通化师范学院学报,2010,31(2):39-41.
[21]李伟平,何良艳,马哲龙,等.土牛膝多糖抗炎镇痛作用的研究[J].中华中医药学刊,2012,30(4):747-749.
[22]Maksimovic Z,Kovacevic N,Lakusic B,et al.Antioxidant activity of yellow dock(L.,Polygonaceae)fruit extract[J].Phytotherapy Research,2011,25(1):101-105.
[23]孙晓龙,王宽宇,张丹琦.土茯苓注射液对大鼠血栓形成影响的实验研究[J].中国中医药科技,2004,11(4):229-231.
[24]Irshad AL,Gurpreet K,Mohammad A,et al.Protective effect of(English Spinach)roots on ferric nitrilotriacetate(Fe-NTA)induced hepatic oxidative stress and tumor promotion response[J].Food Chem Toxicol,2007,45(10):1821-1829.
[25]张燕,李治建,夏木西努尔·肖盖提,等.土大黄化学成分及药理作用研究进展[J].中药药理与临床,2012,28(3):173-176.
[26]袁精玉.土牛膝新鲜品和陈品抗脂质过氧化作用药效比较[J].江西中医学院学报,2007,19(2):79.
[27]陈红明.通痹土茯苓汤治疗急性痛风性关节炎80例观察[J].实用医药杂志,2010,26(8):528-529.
[28]Xia DZ,Yu XF,Liao SP.Protective effect of Smilax glabra extract against lead-induced oxidative stress in rats[J].Journal of Ethnopharmacology,2010(130):414-420.
[29]黄青,瞿幸,吴清.黄连、土大黄、苍术提取液抗银屑病实验研究[J].中国中医药信息杂志,2008,15(6):30-31.
[30]方芳,王立国,李妍,等.羊蹄根对原发性血小板减少性紫癜模型小鼠外周血小板的影响[J].时珍国医国药,2012,23(4):919-920.
[31]马健康,方芳,李艳.羊蹄根对免疫性血小板减少性紫癜小鼠模型的治疗作用[J].中国免疫学杂志,2011,27(4):363-364.
[32]马文杰,魏得良,黄志芳,等.土牛膝提取物对正常及四氧嘧啶糖尿病模型小鼠血糖的影响[J].当代医学,2010,16(30):4-5.